Application of salvianolic acid B in preparing medicine for resisting gastrointestinal tract shield damages

A technology of salvianolic acid and gastrointestinal tract, applied in the application field of salvianolic acid B in the preparation of anti-gastrointestinal barrier damage drugs, can solve the problems of anti-gastrointestinal barrier damage, and achieve the function of avoiding the barrier function of gastrointestinal mucosa No damage, reliable curative effect, fast-acting effect

Inactive Publication Date: 2012-10-10
DALIAN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no related reports about salvianolic acid B having anti-gastrointestinal barrier damage.

Method used

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  • Application of salvianolic acid B in preparing medicine for resisting gastrointestinal tract shield damages
  • Application of salvianolic acid B in preparing medicine for resisting gastrointestinal tract shield damages
  • Application of salvianolic acid B in preparing medicine for resisting gastrointestinal tract shield damages

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] Salvianolic acid B can be extracted by prior art methods. Caco-2 was chosen as an in vitro model for simulating the intestinal barrier. The morphology, physiological function, and enzymes on the surface of the brush border of Caco-2 cells are very similar to those of normal intestinal epithelium. It can be used as an in vitro model for studying intestinal barrier function. The establishment of the experimental cell injury model uses hydrogen peroxide injury to simulate intestinal epithelial injury caused by intestinal ischemia-reperfusion injury and Crohn's disease, colitis, etc., by increasing the level of intracellular oxygen free radicals, causing exogenous intestinal barrier Injury, simulating intestinal mucosal nutrient malabsorption.

[0014] Experimental data:

[0015] one. Experiment of Salvianolic Acid B Improving Intestinal Barrier Function in Vitro

[0016] (1) Experimental method

[0017] 1. Drugs and reagents

[0018] Salvianolic acid B was dissolved i...

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PUM

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Abstract

The invention relates to the application of salvianolic acid in preparing medicine for resisting gastrointestinal tract shield damages, which can prevent various diseases caused by damages to the gastrointestinal mucous membrane shield function, can replace conventional internal nutrition preparation, and has the advantages of reliable curative effect, rapid effect, rich resources, low price and the like.

Description

technical field [0001] The present invention relates to the new application of salvianolic acid B in the preparation of medicine, especially the application of salvianolic acid B in the preparation of anti-gastrointestinal barrier damage medicine. Background technique [0002] Under normal circumstances, bacteria in the intestinal lumen cannot enter the organs and tissues of the whole body through the intestinal wall, because the intestinal mucosa has a barrier function to prevent bacteria and endotoxins. Many studies have shown that stress conditions such as trauma, burns, shock, and infection can cause gastrointestinal mucosal ischemia and hypoxia, ischemia-reperfusion injury, and nutritional disorders, which can cause damage to the gastrointestinal mucosal barrier function and cause bacteria and endotoxins to be displaced. , eventually leading to intestinal-derived systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction (MODS), so preventing and trea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/343A61P1/04
Inventor 孙长凯马骁驰张宝璟王东
Owner DALIAN MEDICAL UNIVERSITY
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