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A cassia seed extract for treating non-alcoholic fatty liver, its preparation method and its pharmaceutical application

A non-alcoholic, cassia seed technology, applied in the field of cassia seed mixed extracts, can solve the problems of poisoning, high irritation, obvious side effects and the like

Inactive Publication Date: 2015-10-28
CHONGQING ACAD OF CHINESE MATERIA MEDICA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Metformin is an insulin sensitizer, which can reduce the levels of plasma free fatty acids and plasma triglycerides by improving the glucose tolerance and hyperinsulinemia of patients, but it has obvious side effects and is very irritating to the gastrointestinal tract. Elderly patients are at risk for lactic acidosis
However, at present, most of the mixed extracts of cassia seeds are used for a single extraction part.

Method used

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  • A cassia seed extract for treating non-alcoholic fatty liver, its preparation method and its pharmaceutical application
  • A cassia seed extract for treating non-alcoholic fatty liver, its preparation method and its pharmaceutical application
  • A cassia seed extract for treating non-alcoholic fatty liver, its preparation method and its pharmaceutical application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The screening of embodiment 1 cassia seed extraction method

[0019] Emodin, cassiatin, orange cassiatin, yellow cassiatin, cassia lactone, chrysophanol-1-beta gentiobioside and other components are mainly anthraquinone compounds, which exist in free and bound states, of which Conjugated anthraquinone-based. Modern pharmacological results show that cassia seed has obvious hypolipidemic effect, and anthraquinone glycoside is one of the main components of hypolipidemic. Considering that the anthraquinone components are unstable when exposed to heat, we designed the percolation extraction method to conduct an orthogonal test, using 1,8-dihydroxyanthraquinone as a standard and its combination with anthraquinone as an index to screen for the best extraction process. And compared with the reflux method and the warm soaking method.

[0020] Comparison of cassia seed percolation method with reflux method and warm immersion method: extract according to the best method selected...

Embodiment 2

[0034] The preparation of embodiment 2 cassia seed mixed extract

[0035] Weigh 10 kg of Semen Cassiae medical material, according to the preferred percolation method described in Example 1 of soaking for 24 hours, alcohol concentration 80%, flow rate 3ml / (min·kg), and ethanol consumption 8 times, to obtain Semen Cassiae ethanol extract.

[0036] After wiping off the ethanol from the Cassia officinalis medicinal material residue at low temperature, the water extract is obtained by extracting by any one of warm soaking extraction, decoction extraction and reflux extraction.

[0037] Combine water extract and ethanol extract to obtain cassia seed mixed extract for treating non-alcoholic fatty liver.

Embodiment 3

[0038] Example 3 Investigation of the activity of cassia seed mixed extract on non-alcoholic fatty liver in rats

[0039] The cassia seed medicinal material is extracted by using ethyl acetate 10 times the weight of the medicinal material as a solvent, and soaked at 40° C. to obtain a cassia seed ethyl acetate extract group. According to the optimized percolation method described in Example 1, the Semen Cassiae ethanol extract group was obtained, and the Semen Cassiae mixed extract group was obtained according to the method described in Example 2; The amount of raw medicinal materials. High-fat feed (2% cholesterol, 0.2% propylthiouracil, 15% lard, 82.8% basic feed), prepared by Chongqing Institute of Traditional Chinese Medicine; 60 SD rats, provided by Animal Center of Chongqing Institute of Traditional Chinese Medicine , Certificate number: SCXK Yu 20070006. TC, TG, LDL-C, HDL-C, ALT, AST kits: Beijing Furui Bioengineering Company; ALT, AST, SOD, MDA kits: Nanjing Jianche...

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Abstract

The invention provides a semen cassiae mixed extract for treating nonalcoholic fatty liver diseases. The mixed extract consists of water extracts of semen cassiae medical materials and ethanol extracts of semen cassiae medical materials. The semen cassiae mixed extract is obtained through combining extraction parts of anthraquinone compounds, unsaturated fatty acid and naphthalene diketopyrrolopyrrole ingredients, the effect for treating the nonalcoholic fatty liver diseases is superior to that of effective parts adopting ethyl acetate for extraction and effective parts only adopting ethanol for extraction, and meanwhile, the mixed extract also has certain treatment effects on diabetic nephropathy.

Description

technical field [0001] The invention relates to an extract of traditional Chinese medicinal materials, and more specifically relates to a mixed extract of cassia seeds for treating nonalcoholic fatty liver, a preparation method and application thereof. technical background [0002] Nonalcoholic fatty liver disease (NAFLD) refers to the clinicopathological syndrome characterized by diffuse hepatic bullous steatosis caused by alcohol and other definite liver damage factors, including simple fat Liver and its evolution steatohepatitis (NASH) and cirrhosis. In recent years, with the improvement of living standards and changes in lifestyles, the incidence of non-alcoholic fatty liver has been increasing. Some studies have shown that the prevalence of NAFLD in the general population of the United States, Western Europe, and Japan is 10% to 24%, while obesity The prevalence of NAFLD is as high as 57.5% to 74%. NAFLD will be the liver disease with the highest incidence in the futu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/482A61P1/16A61P3/10A61P13/12A61K131/00
Inventor 杨大坚陈新滋陈国庆张毅陈士林徐宏喜
Owner CHONGQING ACAD OF CHINESE MATERIA MEDICA