Supported catalyst, as well as preparation method and application thereof in synthesis of 3,4-dihydropyrimidine-2-ketone

Abstract

The invention discloses a supported catalyst, as well as a preparation method and an application of the supported catalyst in synthesis of 3,4-dihydropyrimidine-2-ketone. The supported catalyst takes granular active carbon as a carrier and is formed by absorbing copper chloride; and the loaded and absorbed copper chloride is calculated by mass percent, i.e., the ratio between the granular active carbon and the copper chloride is (85-95%):(15-5%). The supported catalyst is used for the synthetic reaction for preparing the 3,4-dihydropyrimidine-2-ketone so as to enable the synthetic reaction and purification to be completed in one step, thus not only improving the product yield, but also simplifying the operation; and therefore, the production cost is reduced. Finally, the obtained 3,4-dihydropyrimidine-2-ketone is good in color and luster as well as high in purity.

Description

Technical field

[0001] The invention involves a load catalyst and its preparation method and the application in the synthesis of 3,4-dihydrial-2-ketone synthesis, that is, loaded on the activated carbon with Louisic acid, as preparation of 3,4-dihydridine-2-The catalyst used for ketone synthesis reactions is more specifically involved in the catalysts used for 3,4-dihydrial-2-ketone synthesis reactions. Background technique

[0002] 3,4-dihydrial-2-ketone is a drug intermediate with antiviral, antitumor and antibacterial and anti-inflammatory effects, and also has the effects of regulating and lowering blood pressure.Anti -cancer, sterilization and other fields have broad prospects.Therefore, the synthesis of such compounds in recent years has caused great interest.People use various synthesis methods to increase the income of 3,4-dihydrine-2-ketones.However, the color obtained by the synthetic product is yellow and the purity is not high. It must be heavy crystals to obtain prod...