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Chiral ionic liquid magnetic nanoparticle product and preparation method and application thereof

A technology of magnetic nanoparticles and chiral ionic liquids, applied in nanomagnetism, nanotechnology, nanotechnology, etc., can solve the problems of pollution, time-consuming, expensive, etc., and achieve good separation effect, simple and convenient operation, and short separation time short effect

Inactive Publication Date: 2012-10-10
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, a variety of liquid chromatography chiral stationary phases have been developed, such as protein type, Prikle type, polysaccharide derivative type, ligand exchange type and cyclodextrin type, etc., and these separations have extremely high requirements on instrument performance and material purity. Expensive, time-consuming, difficult to recycle and easy to cause waste and pollution, so the development of more effective chiral separation materials is crucial

Method used

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  • Chiral ionic liquid magnetic nanoparticle product and preparation method and application thereof
  • Chiral ionic liquid magnetic nanoparticle product and preparation method and application thereof
  • Chiral ionic liquid magnetic nanoparticle product and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0020] (1) Fe 3 o 4 Preparation of Magnetic Nanoparticles: FeCl 3 .6H 2 Dissolve 0.5g of O, 0.1g of succinic acid, and 0.1g of urea in 30ml of 1,2-propanediol, put them into a 50ml reactor and react at 200°C for 5h. Separate, and finally use ethanol to ultrasonically disperse and store to obtain Fe 3 o 4 magnetic nanoparticles;

[0021] (2) Fe 3 o 4 / SiO 2 Preparation of composite magnetic nanoparticles: weighing the first step product Fe 3 o 4 0.1g, add H 2 In a mixed solvent with a volume ratio of O and EtOH of 1, ultrasonically disperse for 10 min, and add NH under stirring. 3 .H 2 O to adjust the pH to 9, add 0.5ml tetraethyl orthosilicate to the solution, keep the reaction for 4 hours, adjust the pH to 7 with HCl aqueous solution, use an external magnetic field to separate, wash with deionized water and EtOH, and vacuum dry at 50°C After getting the product Fe 3 o 4 / SiO 2 ;

[0022] (3) Preparation of chiral ionic liquid magnetic nanoparticles: the prep...

Embodiment 2

[0024] (1) Fe 3 o 4 Preparation of Magnetic Nanoparticles: FeCl 3 .6H 2 Dissolve 0.6g of O, 0.2g of succinic acid, and 0.2g of urea in 30ml of 1,2-propanediol, put them into a 50ml reactor and react at 200°C for 5h, after cooling, wash them three times with ethanol and deionized water, and use an external magnetic field Separate, and finally use ethanol to ultrasonically disperse and store to obtain Fe 3 o 4 magnetic nanoparticles;

[0025] (2) Fe 3 o 4 / SiO 2 Preparation of composite magnetic nanoparticles: weighing the first step product Fe 3 o 4 0.2g, add H 2 In a mixed solvent with a volume ratio of O and EtOH of 1, ultrasonically disperse for 10 min, and add NH under stirring. 3 .H 2 O to adjust the pH to 9, add 0.5ml tetraethyl orthosilicate to the solution, keep the reaction for 5 hours, adjust the pH to 7 with HCl aqueous solution, use an external magnetic field to separate, wash with deionized water and EtOH, and vacuum dry at 50°C After getting the prod...

Embodiment 3

[0028] (1) Fe 3 o 4 Preparation of Magnetic Nanoparticles: FeCl 3 .6H 2 Dissolve 0.6g of O, 0.3g of succinic acid, and 0.3g of urea in 30ml of 1,2-propanediol, put them into a 50ml reactor and react at 200°C for 6h, after cooling, wash them three times with ethanol and deionized water respectively, and use an external magnetic field Separate, and finally use ethanol to ultrasonically disperse and store to obtain Fe 3 o 4 magnetic nanoparticles;

[0029] (2) Fe 3 o 4 / SiO 2 Preparation of composite magnetic nanoparticles: weighing the first step product Fe 3 o 4 0.3g, add H 2 In a mixed solvent with a volume ratio of O and EtOH of 2, ultrasonically disperse for 20 minutes, and add NH under stirring 3 .H 2 O to adjust the pH to 9, add 0.75ml tetraethyl orthosilicate to the solution, keep the reaction for 6 hours, adjust the pH to 7 with HCl aqueous solution, use an external magnetic field to separate, wash with deionized water and EtOH, and vacuum dry at 60°C After...

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Abstract

The invention relates to a chiral ionic liquid magnetic nanoparticle product and a preparation method and application thereof. The preparation method comprises the following steps: dissolving FeCl3.6H2O, succinic acid and urea into 1,2-propanediol, putting the solution into a reaction kettle, and reacting to obtain an Fe3O4 magnetic nanoparticle; adding the Fe3O4 magnetic nanoparticle into a mixed solvent of H2O and EtOH, adding NH3.H2O and TEOS (tetraethoxysilane), and reacting to obtain Fe3O4 / SiO2; and adding the Fe3O4 / SiO2 into dimethyl sulfoxide, adding 1-alkyl-3-methylimidazolyl-L-proline salt or 1-alkyl-3-methylimidazolyl-L-lactate ionic liquid, and adding hexamethylene-1,6-diisocyanate to obtain the chiral imidazole ionic liquid magnetic nanoparticle. During application of the chiral ionic liquid magnetic nanoparticle to chiral separation of 1-phenyl-1,2-ethylene glycol and 1-hydroxy acenaphthene, the separation time is short, the operation is simple and convenient, and the separation effect of a chiral compound is good.

Description

technical field [0001] The invention relates to a chiral ionic liquid magnetic nano particle product and its preparation and application. Background technique [0002] Chiral compounds refer to molecules with the same molecular weight and molecular structure, but the actual object and its mirror image do not overlap. Two molecules that are real objects and mirror images are enantiomers (referred to as enantiomers). Except for optical activity, enantiomers have the same physical properties, but they will show different functions in a chiral environment. Properties such as enantiomers in drugs, food additives, pesticides, flavorings and fragrances can exhibit differences in pharmacological and clinically useful properties. The separation of chiral compounds has received more and more attention. At present, the separation methods of chiral compounds mainly include chemical resolution, crystallization resolution, biological resolution, membrane resolution and chromatographic re...

Claims

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Application Information

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IPC IPC(8): C07D233/58B82Y30/00B82Y25/00C07B57/00C07C33/26C07C35/37C07C29/74
Inventor 魏芸王雄田爱林
Owner BEIJING UNIV OF CHEM TECH
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