Application of salidroside in preventing and treating amyotrophy diseases

Abstract

The invention relates to an application of salidroside in preventing and treating amyotrophy diseases. Experiments prove that salidroside can inhibit the expression of amyotrophy peculiar factor Atrogin-1, myotube atrophy and reduction of skeletal muscle fiber cross section area during the amyotrophy generating process, and has the functions of increasing the content of slow-twitch fiber protein in skeletal muscle and inhibiting fast-twitch fiber protein expression, and thus the amyotropy is prevented and resisted.

Description

Technical field: [0001] The invention relates to a new application of the compound salidroside, in particular to the application of the salidroside in the preparation of drugs for preventing and treating muscle atrophy. Background technique: [0002] Salidroside (Formula I) is a compound with known chemical structure, English name Salidroside, molecular formula C14H20O7, CAS accession number 10338-51-9. [0003] [0004] Domestic and foreign studies have shown that salidroside plays an important role in anti-fatigue, anti-aging, immune regulation, scavenging free radicals, enhancing memory, and improving sleep. Basic clinical research also suggests that salidroside can significantly reverse renal damage caused by pulmonary hypertension, diabetes or hypoxia, weaken the proliferation and differentiation potential of vascular smooth muscle cells, and interfere with the formation of liver fibrosis. But so far there is no report on the role and mechanism of salidroside in ske...

AI Technical Summary

Problems solved by technology

However, clinical muscular dystrophy diseases (such as Duchenne muscular dystrophy, lateral sclerosis, etc.), disuse muscular atrophy (long-term bed rest, traumatic immobilization, weightlessness muscular atrophy during spaceflight, etc.), denervation / denervation Muscular atrophy, senile muscular atrophy, advanced muscular atrophy of malignant diseases (such as cancer cachexia, heart failure, renal failure, diabetes, chronic obstructive pulmonary disease, AIDS and long-term use of glucocorticoids), etc., skeletal muscle protein metabolism Imbalance, characterized by significant weight loss of skeletal muscle, reduction of muscle fiber cross-sectional area, selective loss of muscle fiber type-related proteins (ie, slow-twitch and fast-twitch proteins), and other characteristic changes, resulting in decreased muscle strength, movement disorders, and easy Fatigue and metabolic disorders, etc., seriously affect daily work and life

However, there is currently no good clinical treatment

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