Application of salidroside in preventing and treating amyotrophy diseases

A technology of salidroside and muscle atrophy, which is applied in muscular system diseases, neuromuscular system diseases, medical preparations containing active ingredients, etc., and can solve the problems affecting daily work and life, fatigue, and disuse muscle atrophy ( Long-term bed rest, traumatic braking, and weightless muscle atrophy during spaceflight, etc., to reduce the expression of muscle atrophy-specific factors and increase the content of slow muscle fiber protein

Inactive Publication Date: 2012-10-17
SCI RES TRAINING CENT FOR CHINESE ASTRONAUTS
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, clinical muscular dystrophy diseases (such as Duchenne muscular dystrophy, lateral sclerosis, etc.), disuse muscular atrophy (long-term bed rest, traumatic immobilization, weightlessness muscular atrophy during spaceflight, etc.), denervation / denervation Muscular atrophy, senile muscular atrophy, advanced muscular atrophy of malignant diseases (such as cancer cachexia, heart failure, renal failure, diabetes, chronic obstructive pulmonary disease, AIDS and long-term use of glucocorticoids), etc., skeletal muscle protein metabolism Imbalance, characterized by significant weight loss of skeletal muscle, reduction of muscle fiber cross-sectional area, selective loss of muscle fiber type-related proteins (ie, slow-twitch and fast-twitch proteins), and other characteristic changes, resulting in decreased muscle strength, movement disorders, and easy Fatigue and metabolic disorders, etc., seriously affect daily work and life
However, there is currently no good clinical treatment

Method used

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  • Application of salidroside in preventing and treating amyotrophy diseases
  • Application of salidroside in preventing and treating amyotrophy diseases
  • Application of salidroside in preventing and treating amyotrophy diseases

Examples

Experimental program
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Embodiment Construction

[0038] The sources of experimental animals and materials used in the following experiments are as follows:

[0039] Experimental animals: male C57 mice were purchased from Beijing Weitong Lihua Animal Center, production license number: SCXK (Beijing) 2012-0001; experimental animal quality certificate number: 0261086.

[0040] The C2C12 cell line was purchased from the Chinese Academy of Medical Sciences.

[0041] Myotubes are the multinucleated syncytia formed by monocyte C2C12 in vitro myogenic differentiation prepared in this experiment.

[0042] Test drug: salidroside, purchased from Chengdu Pusi Biotechnology Co., Ltd., HPLC: 99%.

[0043] Additional material sources:

[0044] Tissue embedding agent was purchased from Thermo company;

[0045] Rabbit-derived laminin antibody was purchased from Abcam;

[0046] Goat anti-rabbit FITC fluorescently labeled secondary antibody was purchased from Invitrogen;

[0047] Goat anti-mouse FITC fluorescently labeled secondary antibo...

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Abstract

The invention relates to an application of salidroside in preventing and treating amyotrophy diseases. Experiments prove that salidroside can inhibit the expression of amyotrophy peculiar factor Atrogin-1, myotube atrophy and reduction of skeletal muscle fiber cross section area during the amyotrophy generating process, and has the functions of increasing the content of slow-twitch fiber protein in skeletal muscle and inhibiting fast-twitch fiber protein expression, and thus the amyotropy is prevented and resisted.

Description

Technical field: [0001] The invention relates to a new application of the compound salidroside, in particular to the application of the salidroside in the preparation of drugs for preventing and treating muscle atrophy. Background technique: [0002] Salidroside (Formula I) is a compound with known chemical structure, English name Salidroside, molecular formula C14H20O7, CAS accession number 10338-51-9. [0003] [0004] Domestic and foreign studies have shown that salidroside plays an important role in anti-fatigue, anti-aging, immune regulation, scavenging free radicals, enhancing memory, and improving sleep. Basic clinical research also suggests that salidroside can significantly reverse renal damage caused by pulmonary hypertension, diabetes or hypoxia, weaken the proliferation and differentiation potential of vascular smooth muscle cells, and interfere with the formation of liver fibrosis. But so far there is no report on the role and mechanism of salidroside in ske...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7032A61P21/00
Inventor 陈晓萍张鹏刘红菊高月范明白延强陈善广
Owner SCI RES TRAINING CENT FOR CHINESE ASTRONAUTS
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