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Oxygen isotope-containing compound, preparation method and application and composition

A technology of oxygen isotopes and compounds, applied in chemical instruments and methods, the application of radioactive source radiation, inorganic chemistry, etc., can solve the problems of short half-life, expensive production costs, unrealistic compounds, etc., and achieve easy operation and easy acquisition , cost-saving effect

Inactive Publication Date: 2012-10-31
BEIJING TOP GRADE HEALTHCARE MEDICAL EQUIP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, containing [ 18 The labeled compound of F] is expensive in terms of production cost, and can only be limited to some limited compounds, that is, only certain groups in the compound can be labeled after being replaced by fluorine, carbon, etc.
[0009] In addition, the preparation of labeled compounds by traditional cyclotrons does not use photonuclear reactions, and requires chemical methods to label the prepared isotopes on the compounds
preparation 15 The nuclear reaction formula of O(oxygen-15) is 15 N(p,n) 15 O and 14 N(d,n) 15 O, and, since 15 The half-life of O is extremely short, only 2 minutes, chemically labeled with 15 Compounds of O isotopes are completely unrealistic

Method used

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  • Oxygen isotope-containing compound, preparation method and application and composition
  • Oxygen isotope-containing compound, preparation method and application and composition
  • Oxygen isotope-containing compound, preparation method and application and composition

Examples

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Effect test

Embodiment 1

[0049] The specific process of this embodiment is: take 2.5g of medical water for injection, remove the air in the water under negative pressure, freeze to 0°C, place the ice water in the sample irradiation chamber of a high-energy accelerator, irradiate at 50 MeV for 5 minutes, and the irradiation rate is 3000Gy (Ge Rui) / min. After irradiation, the water molecules on the 16 O transforms into 15 O, take 10 μl with 15 After the O water was injected through the tail vein of SD rats (outbred group rats), the water imaging of the lungs and brain could be observed.

[0050] Experiments have shown that in this example, a 15 O water. Please see attached figure 1 , with figure 1 prepared in this example 15 The measured radioactive decay curve (oscillation curve) of O water and 15 A comparison plot of the theoretical decay curves of O. From the comparison chart, it can be seen that 15 The measured radioactive decay curve of O water is 15 Oscillation near the theoretical deca...

Embodiment 2

[0055] The specific process of this embodiment is: take 2.5g of medical water for injection, remove the air in the water under negative pressure, freeze to 0°C, place the ice water in the sample irradiation chamber of a high-energy accelerator, irradiate at 51 MeV for 5 minutes, and the irradiation rate is 3000Gy (Ge Rui) / min.

[0056] Other steps are identical with embodiment 1. Obtained the experimental effect basically the same as embodiment 1. The obtained PET labeling pattern is also similar, and the effect difference between embodiment 2 and embodiment 1 cannot be distinguished by the naked eye.

Embodiment 3

[0058] The specific process of this embodiment is: take 2.5g of medical water for injection, remove the air in the water under negative pressure, freeze to 0°C, place the ice water in the sample irradiation chamber of a high-energy accelerator, and irradiate at 49 MeV for 5 minutes at an irradiation rate of 3000Gy (Ge Rui) / min.

[0059] Other steps are identical with embodiment 1. Obtained the experimental effect basically the same as embodiment 1. The obtained PET labeling pattern is also similar, and the effect difference between embodiment 3 and embodiment 1 cannot be distinguished with the naked eye.

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Abstract

The invention relates to an oxygen isotope-containing compound and a preparation method thereof, application of the oxygen isotope-containing compound to positive electron or other nuclide imaging, application of the oxygen isotope-containing compound to an distribution or metabolic image of the oxygen isotope-containing compound in an organism as well as a composition containing the oxygen isotope-containing compound. According to the preparation method of the oxygen isotope-containing compound, x rays, proton lines, heavy particle lines which are respectively generated by a high-energy electron accelerator, protons, heavy ions or neutron treatment equipment radiate on the water, wherein the energy of the rays is 20-430MeV; and under the condition that a water molecule structure is not damaged, oxygen atoms in the water generate oxygen positron nuclide through a photonuclear reaction, and thus the oxygen isotope-containing compound is produced. The oxygen isotope-containing compound disclosed by the invention is used for the organism, so that the distribution or metabolic conditions of the oxygen isotope-containing compound in the organism can be definitely marked. The oxygen isotope-containing compound disclosed by the invention can be used for nuclear medicine equipment such as PET (Positron Emission Tomography) equipment, PET-CT (Positron Emission Tomography-Computed Tomography) equipment, PET-MRI (Positron Emission Tomography-Magnetic Resonance Imaging) equipment, PET-MRI-CT (Positron Emission Tomography-Magnetic Resonance Imaging-Computed Tomography) equipment and mMR (Measles Morbilli Rubeola) equipment.

Description

technical field [0001] The invention relates to an oxygen isotope compound and its preparation method, the application of the oxygen isotope compound in positron or other nuclide imaging, and the distribution of the oxygen isotope compound in the organism after obtaining the oxygen isotope compound or applications in metabolic imaging, compositions comprising the oxygen-containing isotope compound. Background technique [0002] Nuclear medicine examinations, represented by positron emission tomography (abbreviated as PET), scintillation tomography (abbreviated as DS), and single photon emission computed tomography (abbreviated as SPECT), play an important role in diagnosing a variety of diseases, including heart disease and effective in cancer). These techniques involve administering to a patient an agent labeled with a specific radioisotope (abbreviated as a radiopharmaceutical), followed by detection of gamma-rays emitted directly or indirectly from the agent. Compared w...

Claims

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Application Information

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IPC IPC(8): C01B5/00A61K51/00
CPCG21G1/06G21G1/10G21H5/02G21G1/12
Inventor 曾骏张圈世孙启银
Owner BEIJING TOP GRADE HEALTHCARE MEDICAL EQUIP CO LTD
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