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Synthesis of novel chelating agent for treating nickel compound poisoning and preparation method of preparation of novel chelating agent

A nickel compound and compound technology, which can be used in the preparation of sugar derivatives, chemical instruments and methods, anti-toxic agents, etc., can solve problems such as carcinogenicity, and achieve the effects of good nickel-displacing effect, reduction of a-amino acid level, and good protective effect.

Inactive Publication Date: 2012-10-31
程宁 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In addition to nickel carbonyl, the most toxic nickel compound, which can cause acute poisoning, other nickel compounds have chronic toxicity, which can cause chronic poisoning such as allergies and nickel dermatitis, and some are potentially carcinogenic.

Method used

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  • Synthesis of novel chelating agent for treating nickel compound poisoning and preparation method of preparation of novel chelating agent
  • Synthesis of novel chelating agent for treating nickel compound poisoning and preparation method of preparation of novel chelating agent
  • Synthesis of novel chelating agent for treating nickel compound poisoning and preparation method of preparation of novel chelating agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] tablet:

[0023]

[0024] Preparation method: mix the active ingredient, lactose and starch, moisten it evenly with water, sieve the wetted mixture and dry it, then sieve it, add magnesium stearate, and press the mixture into tablets, each tablet is 200mg, and the active ingredient is 10mg .

Embodiment 2

[0026] Capsules:

[0027] BGD 10mg

[0028] Lactose 188mg

[0029] Magnesium stearate 2mg

[0030] Preparation method: mix active ingredients and auxiliary agents, sieve, mix evenly in a suitable container, put the obtained mixture into hard gelatin capsules, each capsule weighs 200 mg, and the content of active ingredients is 10 mg.

Embodiment 3

[0032] Ampoule:

[0033] BGD 2mg

[0034] Sodium chloride 9mg

[0035] Preparation method: Dissolve the active ingredient and sodium chloride in an appropriate amount of water for injection, adjust the pH value to 7.0 with 0.2mol / L HCI, filter the obtained solution, put it into an ampoule bottle under aseptic conditions, and store it in a sterile condition.

[0036] The use experiment effect of the present invention is as follows:

[0037] 1. Observation of the compound of the present invention on the damage repair test of various organs of rats caused by nickel carbonyl acute poisoning.

[0038] SPF grade SD rats were used as the animal model, statically inhaled 250mg / m 3 Nickel carbonyl was exposed for 30 minutes, and after 4 hours and 30 hours, the treatment group was intraperitoneally injected with the present invention. On the 3rd and 7th days, various organs and tissues were collected to observe various indicators.

[0039] Table 1 Tail moment of “Comet” Olive in rat...

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Abstract

The invention relates to a novel chelating agent compound for treating nickel compound poisoning, in particular to synthesis of N-methyl-D-glucose dithiocarbamatre (BGD) and a preparation method of a preparation of the novel chelating agent compound. The compound has a good detoxifying effect in nickel compound poisoning, and particularly has a unique detoxifying effect on kidney injury caused by various nickel compounds. The modular formula of the compound is shown in the specifications.

Description

Technical field [0001] The patent of the present invention relates to a new type of chelating agent compound for the treatment of nickel compound poisoning, that is, the synthesis of sodium N-methyl-D-glucose dithiocarbamate (N-Benzyl-D-glucaminedithiocarbamate, BGD) and its preparation method. The molecular formula of the BGD compound is for: [0002] Background technique [0003] In addition to nickel carbonyl, the most toxic nickel compound, which can cause acute poisoning, other nickel compounds have chronic toxicity, which can cause chronic poisoning such as allergies and nickel dermatitis, and some are potentially carcinogenic. Whether it is acute nickel carbonyl poisoning or chronic nickel poisoning, in addition to symptomatic treatment and infection prevention, chelating agents and other drugs are mainly used for nickel drive treatment. [0004] Chelating agents are metal antidotes that can provide electron pairs to combine with metal ions to form cyclic complexe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/18C07H1/00A61K31/7028A61P39/04
Inventor 程宁王秋英
Owner 程宁