Triptolide and chinese brake herb general flavone combined medicinal composition and preparation and application thereof

A technology of triptolide and Pteris, which is applied in the field of medicine and can solve problems such as unsafe clinical medication

Inactive Publication Date: 2012-11-28
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at the same time, it is a highly toxic drug, LD50 (half lethal dose) is about 0.8mg / kg (oral administration to mice), and has multiple organ toxicity such as liver and kidney. Its effective dose It is very similar to the toxic dose, and the clinical use is very unsafe, which greatly limits the application of triptolide in the treatment of diseases caused by autoimmune system abnormalities such as rheumatoid arthritis, malignant tumors, and organ rejection.

Method used

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  • Triptolide and chinese brake herb general flavone combined medicinal composition and preparation and application thereof
  • Triptolide and chinese brake herb general flavone combined medicinal composition and preparation and application thereof
  • Triptolide and chinese brake herb general flavone combined medicinal composition and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Preparation of the total flavonoids of Pteris vulgaris:

[0020] ① Take 15Kg of Pteris vulgaris, add 6 times the amount of 70% ethanol, heat and reflux for extraction three times, combine the extracts, concentrate, dry, and pulverize to obtain 1550g of Pteris vulgaris total extract.

[0021] ② Make a suspension of the total Pteris fructus extract with an appropriate amount of water, then extract with petroleum ether, ethyl acetate, and n-butanol in sequence, then concentrate the aqueous phase solution under reduced pressure, dry, and pulverize to obtain 1000 g of the water part extract.

[0022] ③ Separate the extract from the water part on a LSA-40 macroporous resin column, elute with water, 10% ethanol, 50% ethanol, and 95% ethanol in sequence, concentrate the 50% ethanol eluate under reduced pressure, dry, and pulverize to obtain Macroporous resin 50% ethanol elution extract 50g.

[0023] ④ Separation of macroporous resin eluted with 50% ethanol on polyamide column,...

Embodiment 2

[0025] Take 1 g of triptolide and 1 mg of total flavonoids of Pteris flavonoids and mix uniformly to obtain a pharmaceutical composition, and add suitable pharmaceutical excipients to the pharmaceutical composition to make pharmaceutically acceptable dosage forms, such as tablets, capsules, oral liquids, etc. , tinctures, granules, ointments, injections, emulsions, dripping pills, sustained-release and controlled-release preparations, pharmaceutical compositions and preparations thereof are used as drugs for treating rheumatoid arthritis, anti-tumor, immunosuppression, and anti-inflammation.

Embodiment 3

[0027] Take 1 g of triptolide and 1 g of total flavonoids of Pteris flavonoids and mix uniformly to obtain a pharmaceutical composition, and add suitable pharmaceutical excipients to the pharmaceutical composition to make pharmaceutically acceptable dosage forms, such as tablets, capsules, oral liquids, etc. , tinctures, granules, ointments, injections, emulsions, dripping pills, sustained-release and controlled-release preparations, pharmaceutical compositions and preparations thereof are used as drugs for treating rheumatoid arthritis, anti-tumor, immunosuppression, and anti-inflammation.

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PUM

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Abstract

The invention belongs to the field of medicines and discloses a triptolide and chinese brake herb general flavone combined medicinal composition and preparation and application thereof. The medicinal composition is prepared by uniformly mixing 1 weight part of triptolide and 10<-3> to 10<5> weight part of chinese brake herb general flavone. The chinese brake herb general flavone is prepared from chinese brake herb through ethanol solution extraction, organic solvent distribution, and macroporous resin and polyamide column refining. The medicinal composition can be applied to preparation of medicines for treating rheumatoid arthritis, anti-tumor medicines, immunosuppression medicines, and anti-inflammatory medicines.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to a pharmaceutical composition compatible with triptolide and total flavonoids of Pteris chinensis, as well as its preparation and application. Background technique [0002] Triptolide is derived from the traditional Chinese medicine Triptolide ( Tripterygium wilfordii The epoxidized diterpene lactone compound isolated in Hook.f.) is one of the main active ingredients of Tripterygium wilfordii. Triptolide has strong pharmacological activity and has significant immunosuppressive, anti-inflammatory, anti-tumor and anti-fertility effects. It is mainly used clinically to treat rheumatoid arthritis, lupus erythematosus, skin diseases, malignant tumors, nephritis and organ Rejection and more than 50 diseases. But at the same time it is a highly toxic drug, LD 50 The (half lethal dose) is about 0.8mg / kg (orally administered to mice). It has toxicity to multiple organs such as liv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/11A61P19/02A61P29/00A61P35/00A61P37/06A61K31/585
Inventor 刘建群舒积成张锐张维潘景行任晓静
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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