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Biomedical calcium phosphate/zinc oxide nano-rod array composite coating on surface of medical metal and preparation method thereof

A zinc oxide nanorod and metal surface technology, which is applied in the fields of metal material coating technology, coating, medical science, etc., can solve the difficulty of coating, the difficulty of adjusting the hydrophobic and hydrophilic properties of the surface, and the hydrophilicity of calcium phosphate coating Poor characteristics and other problems, to achieve the effect of promoting osteogenesis

Inactive Publication Date: 2014-07-23
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although zinc ions can be introduced into the calcium phosphate coating, the hydrophilic properties of the calcium phosphate coating itself are not good, and it is difficult to adjust the hydrophobic and hydrophilic properties of the surface.
Therefore, coatings with the above characteristics are currently difficult to achieve

Method used

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  • Biomedical calcium phosphate/zinc oxide nano-rod array composite coating on surface of medical metal and preparation method thereof
  • Biomedical calcium phosphate/zinc oxide nano-rod array composite coating on surface of medical metal and preparation method thereof
  • Biomedical calcium phosphate/zinc oxide nano-rod array composite coating on surface of medical metal and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1) Preparation of ZnO nanorod arrays grown on the metal surface:

[0029] a. Dissolve zinc acetate and ethanolamine in ethanol at a molar ratio of 1:1 to prepare an ethanol solution of zinc acetate and ethanolamine with a concentration of 0.1M. Take 10 μL of the ethanol solution of zinc acetate and ethanolamine and spin-coat it on medical metal at 5000rpm Surface, heat treatment at 400°C for 0.5h after spin coating to form a medical metal surface with a zinc oxide seed layer for use;

[0030] b. Dissolve zinc nitrate and hexamethylenetetramine in water at a molar ratio of 1:1, and prepare a growth mother solution for the hydrothermal reaction of zinc nitrate and hexamethylenetetramine with a concentration of 0.02M, which will have zinc oxide crystals The medical metal surface of the seed layer and the growth mother liquid were put into the reaction kettle, and after being kept at 80°C for 2 hours, the medical metal surface was cleaned with deionized water and dried to o...

Embodiment 2

[0036] 1) Preparation of ZnO nanorod arrays grown on the metal surface:

[0037]a. Dissolve zinc acetate and ethanolamine in ethanol at a molar ratio of 1:1, prepare an ethanol solution of zinc acetate and ethanolamine with a concentration of 0.75M, take 10 μL of the precursor solution and spin-coat it on the surface of the metal substrate at 5000 rpm, spin-coat After the end, heat treatment at 400°C for 0.5h to form a zinc oxide seed layer;

[0038] b. Dissolve zinc nitrate and hexamethylenetetramine in water at a molar ratio of 1:1, configure the growth mother solution of the hydrothermal reaction of zinc nitrate and hexamethylenetetramine with a concentration of 0.02M, and prepare in a The sample and the growth mother solution were put into the reaction kettle, kept at 80°C for 6 hours, the substrate was taken out and the surface of the sample was cleaned with deionized water and dried to obtain the ZnO nanorod array grown on the metal surface;

[0039] 2) Preparation of b...

Embodiment 3

[0043] 1) Preparation of ZnO nanorod arrays grown on the metal surface:

[0044] a. Dissolve zinc acetate and ethanolamine in ethanol at a molar ratio of 1:1, prepare an ethanol solution of zinc acetate and ethanolamine with a concentration of 0.05M, take 20 μL of the precursor solution and spin-coat it on the surface of the metal substrate at 7000 rpm, spin-coat After the end, heat treatment at 400°C for 1 hour to form a zinc oxide seed layer;

[0045] b. Dissolve zinc nitrate and hexamethylenetetramine in water at a molar ratio of 1:1, configure a growth mother solution for the hydrothermal reaction of zinc nitrate and hexamethylenetetramine with a concentration of 0.05M, and prepare in a. The sample and the growth mother solution were put into the reaction kettle, kept at 100°C for 2 hours, the substrate was taken out, the surface of the sample was cleaned with deionized water and dried, and the array of zinc oxide nanorods grown on the metal surface was obtained;

[0046]...

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Abstract

The invention discloses a biomedical calcium phosphate / zinc oxide nano-rod array composite coating on the surface of a medical metal and a preparation method thereof. The biomedical calcium phosphate / zinc oxide nano-rod array composite coating is obtained by compounding biomedical calcium phosphate and a zinc oxide nano-rod array growing on the surface of a medical metal. One part of the biomedical calcium phosphate / zinc oxide nano-rod array composite coating comprises exposed zinc oxide nano-rod tips and the other part comprises calcium phosphate wrapping zinc oxide nano-rods. The biomedical calcium phosphate / zinc oxide nano-rod array composite coating has light-adjustable surface hydrophilicity and zinc ion slow-release properties. The preparation method comprises the following steps that a zinc oxide nano-rod array grows on the surface of a medical metal matrix with a zinc oxide crystal seed layer by a hydrothermal method; and a calcium phosphate coating is prepared by a sol-gel spin-coating method or a dip-coating method so that a part of zinc oxide nano-rods are exposed and calcium phosphate can wrap and strengthen the zinc oxide nano-rods. The biomedical calcium phosphate / zinc oxide nano-rod array composite coating has adjustable surface hydrophilicity and zinc ion slow-release properties and can be widely used for medical metal implants and other biomedical engineering fields.

Description

technical field [0001] The invention relates to a biomedical coating, in particular to a biomedical calcium phosphate / zinc oxide nanorod array composite coating on the surface of a medical metal. Background technique [0002] Biomedical metal implants play an irreplaceable role in the field of tissue repair. Among them, the improvement of the surface properties of the implant plays a vital role in the initial attachment, proliferation, differentiation, and formation of cell junctions of cells, and the changes in these cell behaviors will directly affect the performance of the implant. Usually, such coatings are calcium phosphate coatings represented by hydroxyapatite and octacalcium phosphate, which are similar to the inorganic components of human bone tissue, such as the coating prepared in Chinese patent CN 201110134974.5. Studies in recent years have found that if the hydrophilicity of the coating surface is enhanced, the osteogenesis of the implant interface can be sign...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/32A61L27/02A61L27/04C23C20/08
Inventor 程逵关振威翁文剑宋晨路杜丕一沈鸽赵高凌张溪文徐刚汪建勋韩高荣
Owner ZHEJIANG UNIV
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