Method for synthesizing magnesium phosphate biological bone cement through self-covering controlled hydration reaction
A technology of hydration reaction and magnesium phosphate, which is used in the preparation of bio-cementing materials and the synthesis of magnesium phosphate biological bone cement by self-coating and controlled hydration reaction, can solve the problem of short curing time and high exothermic temperature of magnesium phosphate biological bone cement. , low clinical performance and other problems, to achieve the effect of excellent biocompatibility, simple and convenient process, and maintaining biocompatibility
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0026] Step 1, self-coating treatment of magnesium oxide
[0027] First, commercially available medical grade MgO and KH 2 PO 4 Ball mill to powders with particle sizes of 6-10μm and 10-20μm respectively. A star-type ball mill was used for ball milling, the milling time was 3h and 4h respectively, the grinding balls were agate balls, the ball-to-material ratio was 1:1, and the speed of the ball mill was 400r / min.
[0028] Then, the ball-milled MgO and the ball-milled KH 2 PO 4 Mix the powder uniformly at a mass ratio of 5:1 to obtain mixture A; add 1ml of distilled water per gram to mixture A while stirring to obtain mixture B, and continue stirring until mixture B solidifies after adding.
[0029] Finally, the mixture B was placed in an environment with a temperature of 37°C and a relative humidity of 100% for 48 hours, and then crushed to a particle size of 15-25 μm using a ball mill, which was the self-coated MgO powder.
[0030] Step 2, reaction-controlled synthesis o...
Embodiment 2
[0033] Step 1, self-coating treatment of magnesium oxide
[0034] First for MgO and KH 2 PO 4 The powder is ball milled, and the specific ball milling conditions are the same as those in Example 1. Then the ball-milled MgO powder and the ball-milled KH 2 PO 4 The powder is mixed uniformly at a mass ratio of 10:1 to obtain a mixture A; and while stirring, add a dilute phosphoric acid solution with a volume concentration of 10% in an amount of 2ml per gram to the mixture A to obtain a mixture B, and continue stirring until Mixture B solidifies. Finally, the mixture B was placed in an environment with a temperature of 37°C and a relative humidity of 100% for 48 hours, and then crushed to a particle size of 15-25 μm using a ball mill, which was the self-coated MgO powder.
[0035] Step 2, reaction-controlled synthesis of magnesium phosphate biocement
[0036] The self-coated MgO powder obtained in step 1 and the KH after ball milling 2 PO 4 Mix the powder uniformly at a ma...
Embodiment 3
[0038] Step 1, self-coating treatment of magnesium oxide
[0039] First for MgO and KH 2 PO 4 The powder is ball milled, and the specific ball milling conditions are the same as those in Example 1. Then the ball-milled MgO powder and the ball-milled KH 2 PO 4Mix the powder uniformly at a mass ratio of 12:1 to obtain mixture A; add glucose solution with a mass concentration of 0.9% to mixture A at an amount of 1.5ml per gram while stirring to obtain mixture B, and continue stirring after the addition until mixture B solidifies. Finally, the mixture B was placed in an environment with a temperature of 37°C and a relative humidity of 100% for 48 hours, and then crushed to a particle size of 15-25 μm using a ball mill, which was the self-coated MgO powder.
[0040] Step 2, reaction-controlled synthesis of magnesium phosphate biocement
[0041] The self-coated MgO powder obtained in step 1 and the KH after ball milling 2 Mix PO4 powder uniformly at a mass ratio of 2:1 to obt...
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More