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Combined live vaccine for muscovy duck parvovirus disease and muscovy duck reovirus disease

A technology for parvovirus and reovirus disease in Muscovy ducks, applied in antiviral agents, virus antigen components, antibody medical components, etc., can solve problems such as economic losses in the Muscovy duck industry and adverse stress reactions in Muscovy duck flocks, and achieve Reduce manpower and material resources, reduce adverse stress reactions, and have good safety effects

Active Publication Date: 2013-01-02
INST OF ANIMAL HUSBANDRY & VETERINARY FUJIAN ACADEMY OF AGRI SCI
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Problems solved by technology

The morbidity rate is 30-90%, and the fatality rate is 60-80%. The undead ducks will become stiff ducks after the disease, causing great economic losses to the Muscovy duck industry.
[0003] At present, Muscovy duck parvovirus disease and Muscovy duck reovirus disease are still important infectious diseases that seriously endanger the Muscovy duck breeding industry. prone to adverse stress responses

Method used

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Embodiment Construction

[0009] The present invention will be further described below in conjunction with specific examples. (but not a limitation of the invention).

[0010] a. Muscovy duck parvovirus attenuated P1 strain (MPV-P1 strain) derived from artificial attenuation. It is artificially bred and weakened by using biotechnologies such as Muscovy duck embryos and Muscovy duck embryo fibroblasts to pass alternately. The pathogenicity of one-day-old muscovy ducklings has the following characteristics (1) Virus titer: MPV-P1 strain is effective against TCID of Muscovy duck embryo fibroblast monolayer cells 50 ≥10 -50 / 0.1ml; (2) safety: use 10 feathers of 1-day-old healthy susceptible young muscovy ducks, inject 0.2 milliliters of the poison seed stock solution into the legs of each feather, observe for 20 days, and all should survive; (3) immunogenicity: One-day-old healthy sensitive muscovy ducklings, intramuscularly inject 0.2 ml into the legs, and the minimum immune dose is 100TCID 50 . The ...

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Abstract

The invention discloses preparation and application of a combined vaccine for a muscovy duck parvovirus disease and a muscovy duck reovirus disease; the combined vaccine adopts a muscovy duck parvovirus attenuated P1 strain (preservation number: CCTCC V201013) and a muscovy duck liver white-spot disease (muscovy duck reovirus disease) attenuated MWCA strain (preservation number: CGMCC 0667) as seed viruses; the seed viruses are proliferated by using muscovy duck embryo fibroblasts and SPF chicken embryo fibroblasts through culture in spinner flasks; the cell viral liquid is gained, mixed according to a proper proportion, and freeze-dried by adding a freeze-drying protective agent to obtain the combined live vaccine; the combined live vaccine is applicable to muscovy duck breeding areas with epidemic muscovy duck three-week diseases and liver white-spot diseases.

Description

technical field [0001] The invention relates to a dual live vaccine of muscovy duck parvovirus disease and muscovy duck reovirus disease, belonging to the field of preventive veterinary medicine. Background technique [0002] Muscovy duck parvovirus disease (commonly known as "three-week disease") is a new disease that first occurred in our province in 1987 in 1-3 week-old young muscovy ducks with diarrhea as the clinical symptom. The disease mainly affects young muscovy ducks of 7-21 days of age, with a morbidity rate of 27-62% and a case fatality rate of 22-43%. Muscovy duck reovirus disease (commonly known as "liver white spot disease", "flower liver disease", "white spot disease", "liver spleen white spot disease" and "Musco duck necrotizing hepatitis" etc.) Muscovy duck breeding areas in Putian, Fuqing, Fuzhou, Changle, Fujian Province, Jinhua, Zhejiang, Foshan, Guangdong and other places occurred clinically with soft feet as the main symptom, with a large number of wh...

Claims

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Application Information

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IPC IPC(8): A61K39/295A61P31/14A61P31/20A61K39/15A61K39/23
Inventor 陈少莺程晓霞林锋强陈仕龙胡奇林林天龙程由铨
Owner INST OF ANIMAL HUSBANDRY & VETERINARY FUJIAN ACADEMY OF AGRI SCI
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