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Preparation method of Pancratistatin

An all-round, flower alkali technology, applied in the direction of organic chemistry, etc., to achieve the effect of short production cycle and easy industrialization

Inactive Publication Date: 2013-01-02
NANJING ZELANG AGRI DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Easy to scale up for industrialization

Method used

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Embodiment 1

[0017] Example 2:

Embodiment 2

[0019] Example 3:

Embodiment 3

[0021] Example 4:

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Abstract

The invention relates to a preparation method of Pancratistatin. The method comprises the following steps of: (1) soaking dry squamous bulbs of Pancratium littorale Jacq. by use of saturated 1% ammonia water for 2-6 hours, airing, adding into a flash-type extractor, carrying out flash-type extraction by using a 85-95% ethanol solution as an extract solvent, and filtering to obtain an extracting solution; (2) concentrating the extracting solution and carrying out alumina column chromatography; and (3) performing prepared liquid phase chromatography separation to obtain the totipotent Velban. The method has the characteristics of rapidness, safety, high efficiency, energy conservation, no damage to effective constituents and the like, and is suitable for industrial production.

Description

technical field [0001] The present invention relates to a kind of preparation method of all-purpose flower alkaloid, particularly relate to a kind of method of flash extracting all-purpose flower alkaloid. Background technique [0002] Pancratistatin, molecular formula C 14 h 15 NO 8 , molecular weight 325.27. Almighty flower alkaloids Pancratium littorale An alkaloid compound isolated from the bulb of Jacq. Experimental studies have shown that Almighty flower alkaloid has: 1. Cytotoxic activity. Very effective against mouse P388, its ED 50 (in vitro) is 0.01μg / ml; in vivo at 0.75-12.5mg / kg, the life extension rate is 38%-106%, and it is also effective for mouse ovarian sarcoma M-5076. 2. Anti-RNA virus activity. After injection of this product to mice infected with Japanese encephalitis, the survival rate increased by 100%, and it was also effective against yellow fever virus and bunyaviruses. 3. Plant growth inhibitors. Inhibits seed germination and plant root g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D491/056
Inventor 苏刘花
Owner NANJING ZELANG AGRI DEV