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Pharmaceutical compositions and therapeutic applications of a hydrocortisone derivative designated as deina

A compound and composition technology, applied in the field of hydrocortisone derivatives, can solve the problems of tissue atrophy of pine derivatives and the unknown application of complications, and achieve the effect of restoring physiological tissue function

Inactive Publication Date: 2013-01-02
乔瓦尼・巴尔科
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the use of hydrocortisone derivatives in the treatment of tissue atrophy and its complications is unknown

Method used

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  • Pharmaceutical compositions and therapeutic applications of a hydrocortisone derivative designated as deina
  • Pharmaceutical compositions and therapeutic applications of a hydrocortisone derivative designated as deina
  • Pharmaceutical compositions and therapeutic applications of a hydrocortisone derivative designated as deina

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0159] Biopsy and Prototype Protocols

[0160] biopsy

[0161] Animal samples biopsied in the study included biopsies of the following:

[0162] - chronic atrophic skin lesions (basal and marginal) due to venous stasis,

[0163] - damage to articular cartilage (chronic degenerative osteoarthritis),

[0164] - Advanced cicatricial scalp (post-traumatic or surgical injury)

[0165] - Hyperkeratosis of the mouth (vitamin B deficiency).

[0166] Disinfect all samples within 10 minutes with normal saline and antibiotics (penicillin 100 units / ml + streptomycin 100 μg / ml + gentamicin 160 mg / L, fluconazole 0.2 mg / ml) at ambient temperature Wash three times.

[0167] The biopsies were then cut into triplicates (two controls to be processed, 1 and 2, and one sample, 3, for each patient) and suspended on 10 cm slides (Lab-Tek chamber slides, Nunc, Kamstrup, Denmark) in the corresponding culture solution within a final volume of 25 ml.

[0168] Two types of controls were prepar...

Embodiment 2

[0265] Cream Form

[0266] In vivo clinical trials 1.

[0267] conduct clinical trials to evaluate the cream Tolerability and efficacy of the products (compositions shown in Table 5) in regeneration and repair of skin and subcutaneous tissue.

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PUM

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Abstract

The invention relates to the hydrocortisone derivative of formula (I), whose IUPAC name is 3-[3, 5-Dihydroxy-3-(2-hydroxy-acetyl)-3a, 6-dimethyl- 7-oxo-dodecahydro-cyclo- penta[alpha]naphthalen-6-yl] -propionic acid, designated as Deina TM , for use in the treatment of atrophic tissues, particularly skin, cartilage, connective, and mucosal tissues and scalp skin.

Description

[0001] The present invention relates to novel therapeutic uses of hydrocortisone derivatives, in particular Deina. More specifically, the invention relates to the use of this derivative in the regeneration of atrophic tissue. The invention also relates to pharmaceutical compositions comprising Deina as active ingredient and their therapeutic use. [0002] The atrophic tissue is in particular skin tissue, skin appendages, mucosal tissue or connective tissue. The present invention relates to compositions effective for the regeneration of all atrophic and / or dystrophic and / or inflamed and / or reactive calcified tissues, in particular by reduction in cell number or size thereof and / or localized area vascularization and / or localized area Tissues of reduced quality due to loss of innervation, preferably with inflammatory factors, with or without necrosis and with or without reactive calcification. [0003] The compositions according to the invention are suitable for formulation and d...

Claims

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Application Information

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IPC IPC(8): A61K31/191A61K9/00A61P17/02A61P19/00A61P1/00A61P9/00A61P11/00A61P5/14A61P5/44A61P25/00A61P27/02A61P29/00A61P37/08A61K8/365A61K45/06
CPCA61K9/0019A61K31/191A61K8/36A61K9/0014A61Q19/08A61K45/06A61P1/00A61P5/14A61P5/44A61P9/00A61P9/10A61P11/00A61P11/02A61P15/00A61P17/00A61P17/02A61P19/00A61P19/02A61P19/04A61P25/00A61P25/02A61P25/28A61P27/02A61P29/00A61P37/08A61P43/00
Inventor 乔瓦尼·巴尔科
Owner 乔瓦尼・巴尔科
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