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Medicine composition containing aspirin, acetaminophen and caffeine and preparation method thereof

A technology of acetaminophen and aspirin, applied in the field of medicine, can solve the problems of salicylic acid gastrointestinal irritation, unfavorable use of patients, and limitation of clinical application, and achieve the effect of avoiding accelerated degradation and inhibiting degradation

Active Publication Date: 2013-01-09
SINOPHARM GUANGDONG GLOBAL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, aspirin is extremely unstable, and the use of general excipients and preparation and storage methods will inevitably cause a large amount of aspirin to degrade, and the degradation product is salicylic acid
However, salicylic acid has strong gastrointestinal irritation, which is not conducive to the use of patients, and thus greatly limits the clinical application of this drug.

Method used

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  • Medicine composition containing aspirin, acetaminophen and caffeine and preparation method thereof
  • Medicine composition containing aspirin, acetaminophen and caffeine and preparation method thereof
  • Medicine composition containing aspirin, acetaminophen and caffeine and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The pharmaceutical composition containing aspirin, acetaminophen and caffeine described in this embodiment is a granule. The specific formula is as follows:

[0033] prescription:

[0034]

[0035]

[0036] Prescription for granule dispensing

[0037] Aspirin coated granules converted according to content

[0038] The coffee coated granules are converted according to the content

[0039] Preparation:

[0040] a. Aspirin, acetaminophen, caffeine, microcrystalline cellulose, and crospovidone are crushed and passed through an 80-mesh sieve;

[0041] B, aspirin, microcrystalline cellulose, crospovidone and silicon dioxide were weighed according to the prescription amount, then mixed for 30 minutes to obtain mixture 1, and aspirin granules were obtained by dry granulation according to conventional methods;

[0042] c, acetaminophen, caffeine, microcrystalline cellulose, crospovidone and silicon dioxide were weighed according to the prescription amount, and then mi...

Embodiment 2

[0047] The pharmaceutical composition containing aspirin, acetaminophen and caffeine described in this embodiment is a capsule. The specific formula is as follows:

[0048] prescription:

[0049]

[0050]

[0051] Capsule filling prescription

[0052] Aspirin coated granules converted according to content

[0053] Coffee coated granules converted according to content

[0054] Preparation:

[0055] a. Aspirin, acetaminophen, caffeine, microcrystalline cellulose, and crospovidone are crushed and passed through an 80-mesh sieve;

[0056] B, aspirin, microcrystalline cellulose, crospovidone and silicon dioxide were weighed according to the prescription amount, then mixed for 30 minutes to obtain mixture 1; according to conventional methods, dry granulation was used to obtain aspirin granules;

[0057] c, acetaminophen, caffeine, microcrystalline cellulose, crospovidone and silicon dioxide were weighed according to the prescription amount, and then mixed for 30 minutes t...

Embodiment 3

[0062] The pharmaceutical composition containing aspirin, acetaminophen and caffeine described in this embodiment is a tablet. The specific formula is as follows:

[0063] prescription:

[0064]

[0065]

[0066]

[0067]

[0068]

[0069] Preparation:

[0070] a. Aspirin, acetaminophen, caffeine, microcrystalline cellulose, and crospovidone are crushed and passed through an 80-mesh sieve;

[0071] B, aspirin, microcrystalline cellulose, crospovidone and silicon dioxide were weighed according to the prescription amount, then mixed for 30 minutes to obtain mixture 1; according to conventional methods, dry granulation was used to obtain aspirin granules;

[0072] c, acetaminophen, caffeine, microcrystalline cellulose, crospovidone and silicon dioxide were weighed according to the prescription amount, and then mixed for 30 minutes to obtain mixture 2; according to conventional methods, dry granulation made the Coffee particles;

[0073] d. According to the abov...

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Abstract

The invention discloses a medicine composition containing aspirin, acetaminophen and caffeine and a preparation method thereof. The medicine composition includes aspirin particles and acetaminophen-caffeine particles, wherein the aspirin particles are prepared by the following compositions by parts of weight: 25 parts of aspirin, 1.8-2.2 parts of microcrystalline cellulose, 0.8-1.2 parts of polyvinylpolypyrrolidone and 0.13-0.15 part of silica; and the acetaminophen-caffeine particles are prepared by the follow compositions by parts of weight: 25 parts of acetaminophen, 6.5 parts of caffeine, 2.3-2.7 parts of microcrystalline cellulose, 0.3-0.7 part of polyvinylpolypyrrolidone and 0.12-0.16 part of silica. The preparation method respectively performs dry palletizing on the aspirin, the acetaminophen and the caffeine and proper accessories, effectively prevents the aspirin from directly contacting with moisture in the air, prevents the acetaminophen from quickening degradation of the aspirin and obviously improves stability of the aspirin contained in the prepared medicine composition.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical composition containing aspirin, acetaminophen and caffeine and a preparation method thereof. Background technique [0002] The composition involved in the present invention contains three components of aspirin, acetaminophen and caffeine. [0003] At present, Aspirin, Acetaminophen and Caffeine Tablets (each containing 0.25g of aspirin, 0.25g of acetaminophen and 65mg of caffeine) are widely used clinically to treat migraine and temporarily relieve mild persistent dull pain and headache, Sinusitis, colds, muscle pain, premenstrual and menstrual pain, pain associated with toothache and mild arthritis pain. The drug has a comprehensive mechanism of action and achieves analgesic effects through multiple mechanisms. [0004] Aspirin mainly inhibits the synthesis of prostaglandins and other substances that can make pain sensitive to mechanical or chemical stimuli (such as br...

Claims

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Application Information

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IPC IPC(8): A61K31/616A61K9/20A61K9/48A61K47/38A61P29/00A61K31/522A61K31/167
Inventor 袁春平黄掌欣贺建春何韵仪郭静冼少华陆启春张远强
Owner SINOPHARM GUANGDONG GLOBAL PHARMA CO LTD
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