Method for reducing viscosity of hyaluronic acid

Abstract

The invention relates to the technical field of hyaluronic acid, and in particular relates to a method for reducing viscosity of hyaluronic acid. The method comprises the following steps of: adding hyaluronic acid into an alkaline organic solvent; adding chloroacetic acid, reacting at the temperature of 30 to 70 DEG C; and performing post-treatment on the reaction solution to obtain low-viscosity hyaluronic acid. According to the method, HA is modified, and carboxymethyl groups are added into the structure, so that HA is modified on the basis that the original property is kept, the viscosity is reduced, and the dissolubility of HA in the aqueous solution is improved, so that the dissolution of HA is fast, HA is convenient to use, hyaluronic acid is conveniently used in cosmetics or foods, the application range of HA is widened, and the using amount of HA is improved.

Description

technical field

[0001] The invention relates to the technical field of hyaluronic acid, in particular to a method for reducing the viscosity of hyaluronic acid. Background technique

[0002] Hyaluronic acid (HA) is an acidic mucopolysaccharide composed of (1-β-4) D-glucuronic acid and (1-β-3) N-acetyl-D-glucosamine disaccharide repeat The straight-chain polysaccharides composed of units are widely distributed in the interstitium of various tissues and cells of vertebrates, and are relatively high in cockscombs, vitreous humors, umbilical cords, skin and synovial fluid. It is also distributed in the capsule of Streptococcus. HA has high viscoelasticity, unique moisture retention, excellent biocompatibility and degradability, and is widely used in cosmetics, plastic surgery, medicine and food industries.

[0003] HA is a polysaccharide with relatively large molecular weight and has a strong viscosity. When the amount of HA added to cosmetics or food exceeds the specified ...