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Shitake extractive sustained-release pellet and preparation method thereof

A technology of shiitake mushroom extract and sustained-release pellets, applied in food preparation, food science, drug combination, etc., can solve the problems of low bioavailability point, gastric mucosal irritation, long disintegration time, etc., and achieve improved bioavailability , Less amount of excipients, good reproducibility of curative effect

Inactive Publication Date: 2013-02-06
JIANGSU BOJIETE MINE MACHINERY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The products of shiitake mushroom extract are well recognized by consumers. These products are basically ordinary tablets and capsules. However, the above-mentioned dosage forms have a long disintegration time and disintegrate at a certain point in the body, which has a certain effect on the gastric mucosa. Irritation, low bioavailability point and other shortcomings, based on the above problems, we will quickly introduce the pellet technology in the field of medicine to the field of food

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Lentinus edodes extract sustained-release pellets are prepared from lentinus edodes extract and pharmaceutical excipients, wrapped with a sustained-release film, which includes polymer materials, porogens and anti-adhesives, and the polymer material is B base cellulose; porogen is povidone; anti-adhesive is silicon dioxide, mushroom extract accounts for 20% of the weight percent of pellet preparation, and sustained-release coating accounts for 2% of the weight percent of pellet preparation. %, pharmaceutical excipients include starch and methylcellulose, excipients account for 73% of the weight percent of the pellet preparation, and binders account for 5% of the weight percent of the pellet preparation.

[0019] The preparation method of mushroom extract sustained-release pellets comprises the following steps:

[0020] a. Take the mushroom extract, add medicinal excipients and mix evenly, prepare soft materials, and prepare drug-containing micropill cores through a gran...

Embodiment 2

[0024] Lentinus edodes extract sustained-release pellets are prepared from lentinus edodes extract and pharmaceutical excipients, wrapped with a sustained-release film, which includes polymer materials, porogens and anti-adhesives, and the polymer material is B base cellulose; porogen is povidone; anti-adhesive is silicon dioxide, mushroom extract accounts for 30% of the weight percent of pellet preparation, and slow-release coating accounts for 5% of the weight percent of pellet preparation. %, pharmaceutical excipients include lactose and polyethylene glycol, excipients account for 60% of the weight percent of the pellet preparation, and binders account for 5% of the weight percent of the pellet preparation.

[0025] The preparation method of mushroom extract sustained-release pellets comprises the following steps:

[0026] a. Take the mushroom extract, add medicinal excipients and mix evenly, prepare soft materials, and prepare drug-containing micropill cores through a gran...

Embodiment 3

[0030] Lentinus edodes extract sustained-release pellets are prepared from lentinus edodes extract and pharmaceutical excipients, wrapped with a sustained-release film, which includes polymer materials, porogens and anti-adhesives, and the polymer material is B base cellulose; porogen is povidone; anti-adhesive is silicon dioxide, mushroom extract accounts for 40% of the weight percentage of pellet preparation, and sustained release film accounts for 8% of the weight percentage of pellet preparation %, the pharmaceutical excipients include dextrin and polyethylene glycol, the excipient accounts for 50% of the weight percentage of the pellet preparation, and the binder accounts for 2% of the weight percentage of the pellet preparation.

[0031] The preparation method of mushroom extract sustained-release pellets comprises the following steps:

[0032] a. Take the mushroom extract, add medicinal excipients and mix evenly, prepare soft materials, and prepare drug-containing micro...

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PUM

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Abstract

The invention discloses a shitake extract sustained-release pellet which is prepared from shitake extractives and pharmaceutical accessories and are externally coated by sustained-release films; each sustained-release film comprises a polymer material, a pore-foaming agent and an anti-bonding agent; the shitake extractives are 20-40% of the weight percentage content of a pellet preparation, and the sustained-release film is 2-10% of the weight percentage content of the pellet preparation; the pharmaceutical accessories consist of an excipient and a binder, wherein the excipient is 50-75% of the weight percentage content of the pellet preparation, while the binder is 1-5% of the weight percentage content of the pellet preparation. The sustained-release pellet prepared by using the preparation method of the shitake extractive sustained-release pellet can be used for adjusting the immunity, and the area of the sustained-release pellet on the surface of an absorbing organ is increased, so that the bioavailability is increased and the local stimulation is reduced or avoided.

Description

technical field [0001] The invention relates to a sustained-release pellet of mushroom extract. [0002] The invention also relates to a preparation method of the mushroom extract sustained-release pellets. Background technique [0003] Shiitake mushrooms can increase energy, treat colds and remove intestinal parasites. The key ingredient of shiitake mushrooms is Xianggu polysaccharide. The products of shiitake mushroom extract are well recognized by consumers. These products are basically ordinary tablets and capsules. However, the above-mentioned dosage forms have a long disintegration time and disintegrate at a certain point in the body, which has a certain effect on the gastric mucosa. Irritation, low bioavailability point and other shortcomings, based on the above problems, we quickly introduced the pellet technology in the field of medicine to the field of food. Therefore, it is necessary to provide a new technical solution to solve the above problems. Contents of ...

Claims

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Application Information

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IPC IPC(8): A23L1/29A23L1/28A61K36/06A61K9/16A61P11/00A61P33/00A23L33/00
Inventor 吴国忠
Owner JIANGSU BOJIETE MINE MACHINERY
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