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Tetradotoxin mask and preparation method thereof

A technology of tetrodotoxin and filming, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and sheet delivery, etc., to achieve the effects of increasing toxin production, shortening onset time, and improving safety.

Active Publication Date: 2014-05-28
河北施坦纳生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Botulinum toxin has been used as the main drug for beauty and wrinkle removal for many years. However, botulinum toxin is mainly injected, which is painful and needs to be implemented by professionals in specialized beauty institutions.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0021] The present invention will be further described in detail below in conjunction with the examples (the following medicines are counted in parts by mass).

[0022] The medicine in embodiment 1~5 is evenly coated on medical gauze or made into patch, the thickness of medicine is as the criterion that can cover gauze, can be used for antipruritic and analgesic; The medicine in embodiment 7~9 is evenly coated It can be used on facial mask paper or made into a film for beauty and wrinkle removal.

[0023] The preparation steps are:

[0024] A. Tetrodotoxin extraction:

[0025] Collect the tetrodotoxin dialysis culture, then centrifuge at 0°C, take the supernatant, mix it with picric acid at a ratio of 1.1:1, mix the resulting mixture with boiling water at a ratio of 1:6, and filter while hot ;

[0026] Cool the filtrate to obtain a crystalline precipitate, separate the crystalline precipitate, and recrystallize the precipitate three times in boiling water to obtain a yell...

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PUM

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Abstract

The invention discloses a tetradotoxin mask and a preparation method of the mask. The tetradotoxin mask comprises an active pharmaceutical ingredient tetradotoxin, stabilizer lactose, a complex solubilizer citric acid, zinc oxide, rosin, vaseline and mint essential oil and the like. Based on different amounts of tetradotoxin contained in the mask, the mask has the effects of relieving itching, easing pain and lifting face. The tetradotoxin mask changes the traditional administration manner of tetradotoxin, and is more convenient to use. The tetradotoxin mask is low in price, simple and easy to manufacture, fast in effect, long in lasting time, healthy and clean. In addition, the mask further conquers the social safety hazard caused by the original tetradotoxin injection is missed, and facilitates promoting normalization of the face lifting item. The consumer can quickly, conveniently and comfortably care the skins without beautifying medical institutions.

Description

technical field [0001] The invention relates to a tetrodotoxin medicine for external use, in particular to a tetrodotoxin patch. Background technique [0002] Tetrodotoxin (TTX for short), is a small molecular weight, non-protein compound, its molecular formula: C 11 h 17 N 3 o 8 , with a molecular weight of 319.27. Tetrodotoxin has a local stimulating effect on the intestinal tract. After entering the organism and being absorbed, it acts on nerve endings and nerve centers through blood circulation, and can block voltage-dependent sodium ions on nerve excitatory membranes with high selectivity and high affinity. channel, thereby blocking the biological potential, inhibiting the excitatory conduction between nerves and muscles, and eventually leading to related physiological dysfunction, mainly manifested as muscle and nerve paralysis, and can play an analgesic, anesthesia, drug detoxification and other effects. It is mainly used in clinical medicine, surgery, dermatolog...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/529A61P17/04A61P17/16A61P29/02
Inventor 林涛武斌
Owner 河北施坦纳生物科技有限公司
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