Preparation method and biological application of T1-T1 synergistic effect gadolinium chelate manganous-manganic oxide nano particle

A nanomanganese tetraoxide, T1-T1 technology, applied in manganese oxide/manganese hydroxide, nanotechnology for materials and surface science, nanotechnology, etc., can solve problems such as nanoparticle research methods that have not been seen, Achieve the effect of low price, good stability and easy access to raw materials

Active Publication Date: 2013-02-13
SHANGHAI NORMAL UNIVERSITY
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Problems solved by technology

[0007] After extensive retrieval of domestic and foreign patent documents and publications, the

Method used

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  • Preparation method and biological application of T1-T1 synergistic effect gadolinium chelate manganous-manganic oxide nano particle
  • Preparation method and biological application of T1-T1 synergistic effect gadolinium chelate manganous-manganic oxide nano particle
  • Preparation method and biological application of T1-T1 synergistic effect gadolinium chelate manganous-manganic oxide nano particle

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Embodiment Construction

[0037] The preparation method of manganese-gadolinium-chelated trimanganese tetroxide nanoparticles includes the following steps:

[0038] (1) Preparation of acetylacetonate manganese precursor:

[0039] Take 2.5 grams of MnCl 2 ·4H 2 O was dissolved in 15mL water; add 5.0mL acetylacetone to the above solution; stir at room temperature for 30min; add 5.0mL triethylamine; extract the yellow precipitate in the reaction solution and filter;

[0040] Prepare a mixed solution of ethanol and water with a volume ratio of 4:1, add the yellow solid obtained by extraction and filtration to the mixed solution of ethanol and water, heat to 75-80°C, stir until completely dissolved to make the solution brown and transparent; cool at room temperature , Filter the yellow needle-like crystals in the solution to obtain the acetylacetonate manganese precursor;

[0041] (2) Preparation of surface oleylamine coordination oil-soluble manganese tetroxide nanoparticles seeds:

[0042] Dissolve 0.4 g of the ma...

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Abstract

The invention discloses a preparation method and biological application of T1-T1 synergistic effect gadolinium chelate manganous-manganic oxide nano particles. The preparation method and the biological application of the T1-T1 synergistic effect gadolinium chelate manganous-manganic oxide nano particles include that firstly manganeseacetylacetonate is combined, and then oleylamine is used as a solvent, a high-temperature pyrolysis method is used to combine oil solubility manganous-manganic oxide nano particles, and then a ligand exchange method is utilized to use alendronate to be exchanged on the surfaces of the manganous-manganic oxide nano particles, so that nano particles are formed, wherein the surfaces of the nano particles are provided with a large number of amino groups. Then, the surfaces of the amino groups are connected with diethylenetriamine pentaacetic acid, so that the surfaces of the nano particles are provided with a large number of carboxyl groups, and at last a chelate effect is utilized to enable the large number of carboxyl groups and gadolinium to be chelated. Therefore, gadolinium chelate manganous-manganic oxide nano particles are obtained. The preparation method is low in requirement for equipment, convenient for operated process, low in needed raw material cost, and nuisanceless in accessory products. And at last through in vitro and in vivo magnetic resonance imaging experimental testing, so that compared with independent manganese and independent gadolinium, T1 magnetic resonance imaging contrast effect is strengthened.

Description

Technical field [0001] The present invention belongs to the technical field of contrast agents, and relates to a preparation method of an enhanced imaging contrast agent and its biological application, specifically a T 1 -T 1 The preparation method of synergistic gadolinium chelated trimanganese tetroxide nanoparticles and its biological application. Background technique [0002] Since the birth of CT, imaging medicine has gone through a period of rapid development for 40 years. Today, we have extremely powerful imaging equipment: 320-slice CT, 7T magnetic resonance, PET-CT, the limit of the display capacity of an imaging equipment is determined by its principle. CT is to use X-ray plus rotating acquisition to image. The imaging time is at the sub-second level. The slip ring will inevitably vibrate during the rotation, the X-ray intensity is constantly fluctuating, and the human blood and organs are in motion. All these determine that its spatial resolution can only be limited ...

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Application Information

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IPC IPC(8): C01G45/02B82Y30/00A61K49/06
Inventor 杨仕平汪娟娟周治国陈冬梅杨昕仪孔斌
Owner SHANGHAI NORMAL UNIVERSITY
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