Preparation method for cefazedone sodium with low water content

A technology of cefazedone sodium and water content, which is applied in the field of medicine, can solve the problems of low drying efficiency and difficulty in reproducing product moisture control, and achieve the effects of long crystallization time, ensuring reproducible consistency, and reducing water content
CN102924482BActive Publication Date: 2015-03-04天津新丰制药有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
天津新丰制药有限公司
Publication Date
2015-03-04

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Abstract

The invention relates to a preparation method for cefazedone sodium with low water content. The method includes the following steps: performing salifying: placing cefazedone and sodium methoxide into dried methyl alcohol for a salifying reaction, and cooling a reaction solution to 10-30DEG C when the cefazedone is completely dissolved; decoloration: adding activated carbon into the reaction solution, stirring for decoloration, filtering out the activated carbon, and then performing ultrafiltration; crystallization; and drying: filtering and washing filter cake to obtain the cefazedone sodium with low water content. According to the method, the cefazedone and sodium methoxide are placed into the dried methyl alcohol for the salifying reaction so as to obtain cefazedone sodium with low water content, and simultaneously, ultrafiltration and ultrasonic crystallization technologies are adopted to produce the cefazedone sodium which is low in water content, few in impurities, uniform in particles, good in liquidity and high in stability.
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Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to a preparation method of cefazedone sodium with low water content. Background technique

[0002] Cefoxitone Sodium is the first generation cephalosporin researched and developed by E.Merck, Darmstadt laboratory. In 1979, E.Merck was the first to go on the market in Germany, and then in its surrounding areas and South Korea, Romania, Bulgaria, Taiwan, etc. Listed in countries and regions, its English name is Cefazedone Sodium; chemical name is (6R,7R)-7-(2-(3,5-dichloro-4-oxo-1(4H)-pyridyl)acetamido) -3-(((5-methyl-1,3,4-thiodiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0 ] Sodium oct-2-ene-2-carboxylate.

[0003] Its chemical structural formula is:

[0004]

[0005] The above structure of cefoxitone sodium is similar to that of cefazolin sodium, both of which are β-lactam antibiotics.

[0006] Cefoxizone sodium against Staphylococcus aureus, coagulase-negative sta...

Claims

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