A photonic crystal fiber sensor
A photonic crystal fiber, optical fiber technology, applied in cladding fiber, optical waveguide light guide, nanotechnology for sensing, etc., can solve the problems of unreliable liquid detection SERS platform, hollow core damage, etc.
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[0060] Embodiments of the present invention provide a photonic crystal fiber (PCF) and a PCF-based SERS detection platform for detecting protein concentrations on the order of picogram levels in nanoliter level sample volumes. Embodiments of the present invention further provide an in vivo tunable SERS detection platform within HCPCF using metallic nanoshells / nanorods.
[0061] The inventors have performed comparative SERS studies on a normal optical fiber (NF) with a core diameter of about 1 millimeter (mm) and a hollow core PCF (HCPCF) with a core diameter of about 6 microns (μm). The SERS active substrate is fabricated within the NF by metal film-on-nanosphere (MFON) technology, in which polystyrene beads with a diameter of about 400 nanometers (nm) are densely packed at the core at the detection end, followed by 20 nm silver (Ag) coating. The SERS active region was fabricated in HCPCF by dipping the probe end of the fiber into a 40 nm citrate-stabilized gold (Au) colloida...
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