Method for preparing clindamycin phosphate

Abstract

The invention relates to a method for preparing clindamycin phosphate, belonging to the field of medicine technologies. According to the method, clindamycin phosphate containing dehydro-clindamycin phosphate is taken as a raw material and dissolved into water or water-containing alcoholic liquid, 1 / 5-1 / 100 of the raw material amount of palladium carbon is added, hydrogen is introduced to react for 1-48 hours while stirring, the dehydro-clindamycin phosphate is enabled to fully produce the clindamycin phosphate, and then crystallization is carried out. The method has the advantages that the dehydro-clindamycin phosphate can be enabled to fully produce the clindamycin phosphate, so that the content of impurities in drugs is reduced, and the quality of the drugs is improved.

Description

technical field

[0001] The invention belongs to the technical field of medicine, and relates to a high-purity clindamycin phosphate and a preparation method thereof. Background technique

[0002] Clindamycin phosphate is an antibiotic semi-synthesized from lincomycin, and its structure is shown in formula 1:

[0003]

[0004] Formula 1 Clindamycin Phosphate

[0005] Clindamycin phosphate is a prodrug, which has no antibacterial activity in vitro. After entering the human body, it is rapidly hydrolyzed into clindamycin, and achieves antibacterial effect by inhibiting the synthesis of bacterial cell wall proteins. Clinically, it is mainly used for various infections caused by anaerobic bacteria and Gram-positive aerobic bacteria, such as respiratory tract infection, urinary tract infection, bone and joint infection, pelvic infection, abdominal infection, skin and soft tissue infection caused by sensitive bacteria .

[0006] According to the research on clindamycin phosph...

Images