Preparation method for cefaclor granule composition
A technology of Clorox granules and cefaclor, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problems of unfavorable drug administration for children, and achieve low cost and excellent preparation technology. simple effect
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Embodiment 1
[0021] The preparation methods of the bitter-free cefaclor granule composition, it comprises the following steps: (1) preparation concentration is the carrageenan solution of 5%: get carrageenan 10g, add 200ml hot water and make dissolving, cool to room temperature, use 0.1mol / L sodium hydroxide solution to adjust the pH to 5.5, for later use; weigh 105 g of cefaclor, add carrageenan solution, make it wet and repeat the granulation in a swing granulator, dry for 4 hours, and pulverize to make cefaclor Carrageenan granule; (2) preparation concentration is 5% sodium chloride solution 25ml, regulates pH to be 8.5 with 0.1mol / L sodium hydroxide solution, for subsequent use; Add chlorine to the cefaclor carrageenan granule in step (1) Sodium chloride solution, wet and solidified, dried at 65°C for 4 hours, prepared into cefaclor inclusion compound; (3) Weighed 2kg sucrose, 200g starch, 15g sodium carboxymethylcellulose, and mixed them in a wet mixing granulator Dry mix for 500-600...
Embodiment 2
[0023] The preparation methods of the bitter-free cefaclor granule composition, it comprises the following steps: (1) preparation concentration is the carrageenan solution of 10%: get carrageenan 20g, add 200ml hot water and make dissolving, cool to room temperature, use 0.1mol / L sodium hydroxide solution to adjust the pH to 5, and set aside; weigh 100 g of cefaclor, add carrageenan solution, make it wet and repeat the granulation in a swing granulator, dry for 5 hours, and pulverize to make cefaclor Carrageenan granule; (2) preparation concentration is 10% sodium chloride solution 25ml, regulates pH to be 9 with 0.1mol / L sodium hydroxide solution, for subsequent use; Add chlorine to the cefaclor carrageenan granule in step (1) Sodium chloride solution, wet and solidified, dried at 75°C for 5 hours, prepared into cefaclor inclusion compound; (3) Weighed 1.5kg sucrose, 200g starch, 12g sodium carboxymethylcellulose, mixed in a wet granulator Medium dry mixing for 500-600 secon...
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