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Method for preparing acetophenone

A technology of acetophenone and sec-butylbenzene, which is applied in the field of preparation of acetophenone, can solve problems such as the preparation of acetophenone, and achieve the effects of stable source of raw materials, easy operation and low price

Active Publication Date: 2013-03-20
CHINA PETROCHEMICAL CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The preparation methods of acetophenone published so far are all using benzene or ethylbenzene as raw materials, and there is no report on the preparation of acetophenone as a raw material with sec-butylbenzene

Method used

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  • Method for preparing acetophenone

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Experimental program
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Effect test

Embodiment 1

[0022] Add 259 grams of sec-butylbenzene with a purity of 98.67% into an autoclave with a volume of 500 ml, then add 0.5 grams of NaOH and 2 ml of water, seal it, and heat the mixture to 130 ° C at a mechanical stirring speed of 700 rpm, and adjust the pressure adjustment The valve keeps the pressure in the kettle at 0.2M Pa. After 6 hours of reaction, a sample is taken for GC analysis. The conversion rate of sec-butylbenzene is 17.8%, and the selectivity of acetophenone is 15.2%.

Embodiment 2

[0024] Add 259 grams of sec-butylbenzene with a purity of 98.67% into an autoclave with a volume of 500 ml, then add 0.5 grams of Na2CO3 and 2 ml of water, seal it, and heat the mixture to 130 ° C at a mechanical stirring speed of 700 rpm, and adjust the pressure adjustment The valve keeps the pressure in the kettle at 1.2 MPa. After 9 hours of reaction, a sample is taken for GC analysis. The conversion rate of sec-butylbenzene is 27.6%, and the selectivity of acetophenone is 14.3%.

Embodiment 3

[0026] Add 259 grams of sec-butylbenzene with a purity of 98.67% into an autoclave with a volume of 500 ml, then add 0.5 grams of Na2CO3 and 2 ml of water, seal it, and heat the mixture to 180 ° C at a mechanical stirring speed of 700 rpm, adjust the pressure adjustment The valve keeps the pressure in the kettle at 1.2 MPa. After 9 hours of reaction, a sample is taken for GC analysis. The conversion rate of sec-butylbenzene is 76.1%, and the selectivity of acetophenone is 67.5%.

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Abstract

The present invention relates to a method for preparing acetophenone, and belongs to the field of organic chemical technology. Specifically, the acetophenone is prepared via oxidation of sec-butylbenzene by using molecular oxygen-containing gas under conditions of a certain temperature and a pressure and the existence of an alkaline buffer. Compared with existing methods, the method has the advantages of low cost of raw materials, simple process, no catalysts, no corrosive waste generated during the reaction, and little harm to the environment.

Description

Technical field: [0001] The invention relates to a preparation method of acetophenone, which belongs to the technical field of organic chemical industry. Background technique: [0002] Acetophenone is an important organic synthesis intermediate, which is widely used in the manufacture of spices, drugs and other organic synthesis raw materials. It can also be used as a solvent for cellulose ethers, cellulose esters and resins, and for plasticizing plastics, etc. agent has broad application prospects. [0003] There are many traditional methods for synthesizing acetophenone, the most commonly used ones are Friedel-Crafts acylation and ethylbenzene oxidation. The Friedel-Crafts acylation method is prepared by reacting benzene with acetyl chloride, acetic anhydride or acetic acid under the catalysis of stoichiometric anhydrous aluminum trichloride. This synthesis method produces a large amount of poisonous and corrosive waste liquid, consumes a large amount of catalyst, is dif...

Claims

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Application Information

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IPC IPC(8): C07C49/78C07C45/36
Inventor 张庆忠潘罗其杜建文曾光乐童莉赵凯晔
Owner CHINA PETROCHEMICAL CORP
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