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Cabazitaxel lipid microsphere injection and preparation method thereof

A technology for lipid microspheres and injections, applied in the field of medicine, can solve problems such as unreported research on lipid microspheres, and achieve the effects of being conducive to long-term placement, good product stability, and simple and feasible preparation process

Inactive Publication Date: 2013-04-03
CHANGZHOU TARGET MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] At present, there is no report on the lipid microsphere research of Cabazitaxel

Method used

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  • Cabazitaxel lipid microsphere injection and preparation method thereof
  • Cabazitaxel lipid microsphere injection and preparation method thereof
  • Cabazitaxel lipid microsphere injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation of embodiment 1Cabazitaxel-egg yolk lecithin complex

[0038] Take 1g of Cabazitaxel, 30g of egg yolk lecithin, slowly add 25ml of chloroform, immerse the phospholipid and drug in chloroform, heat and reflux at 60°C for 2 hours to obtain a clear reaction solution, dry under reduced pressure to remove chloroform, and obtain the drug-loaded phospholipid The compound is airtightly packaged and stored in the refrigerator.

Embodiment 2

[0039] The preparation of embodiment 2Cabazitaxel-soybean lecithin complex

[0040] Take 1g of Cabazitaxel, 30g of soybean phospholipid, add 30ml of ethyl acetate, immerse the phospholipid and drug in ethyl acetate, heat and reflux at 60°C for 1 hour, and remove the ethyl acetate by rotary evaporation to obtain drug-loaded soybean phospholipid complex Items, airtightly packaged, stored in the refrigerator.

Embodiment 3

[0041] Embodiment 3Cabazitaxel-preparation of synthetic phospholipid complex

[0042] Put 1 g of Cabazitaxel and 30 g of synthetic lecithin in a round-bottomed flask, slowly add ether to immerse the phospholipid and drug in the ether, heat and reflux at 60°C for 2 hours to obtain a clear reaction solution, and evaporate the solvent to dryness, namely Get Cabazitaxel phospholipid complex.

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Abstract

The invention discloses a Cabazitaxel phospholipid complex and a method for preparing a lipid microsphere injection which contains the phospholipid complex. The lipid microsphere injection consists of Cabazitaxel, injection phospholipid, injection oil, an emulsifying agent, a stabilizing agent, an antioxidant, an isoosmotic adjusting agent and water for injection. The lipid microsphere injection has the characteristics of high drug-loading rate, slow releasing, small adverse reaction, simplicity and practicability in preparation technology, good product stability and the like and is beneficial to clinic application and industrial production.

Description

field of invention [0001] The invention relates to the technical field of medicine, specifically a Cabazitaxel phospholipid complex, a lipid microsphere injection containing the phospholipid complex and a preparation method thereof. Background of the invention [0002] Cancer is a serious threat to human life and health. With the improvement of industrialization, the aggravation of environmental pollution and the general extension of human life expectancy, the incidence of cancer will increase. About 10 million people are newly diagnosed with cancer every year in the world, and 6 million people die. In China, about 1.7 million people are newly diagnosed with cancer every year, and 1.2 million people die. Cancer has become the first and third cause of death in both urban and rural areas. Undoubtedly, China, which accounts for 1 / 4 of the world's population, is facing the arduous task of getting rid of the threat of cancer as soon as possible and conquering tumors. [0003] P...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/337A61K47/24A61K47/44A61P35/00
Inventor 刘珂郎跃武韩飞
Owner CHANGZHOU TARGET MEDICINE TECH CO LTD
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