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Compound injection containing 18 amino acids and preparation method thereof

A technology of injection and amino acid, applied in the field of medicine, to achieve the effect of improving stability, stable quality and ensuring the quality of finished products

Active Publication Date: 2014-01-22
沈阳海思科制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that in the case of sufficient heat supply, infusion of an appropriate amount of amino acid solution can make the body enter a positive nitrogen balance state, but the effect of positive nitrogen balance obtained by infusion of different types of amino acid solutions is different. Promote the body to enter the positive nitrogen balance stage as soon as possible

Method used

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  • Compound injection containing 18 amino acids and preparation method thereof
  • Compound injection containing 18 amino acids and preparation method thereof
  • Compound injection containing 18 amino acids and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0047] Preparation process table of subdivided embodiments of the present invention

[0048]

experiment example 1

[0057] Experimental example 1-preparation process is to the investigation of the influence of preparation stability of the present invention

[0058] Get each 5 injection finished products of Examples 1-8 and Comparative Examples 1-8, retain samples under the condition of 25 ℃, measure the relative percentage content of tryptophan and cysteine ​​with relatively poor stability, investigate The influence of the preparation process on the stability of the preparation.

[0059]

[0060] *Significantly different from the control

[0061]

[0062]

[0063] *Significantly different from the control

[0064] Through this experiment, it can be concluded that the preparation method of the present invention can significantly improve the stability of the injection.

experiment example 2

[0065] Experimental Example 2—Vascular Irritation Test

[0066] The results of the vascular irritation test showed that the compound injection of the present invention (Example 1-20) had no hyperemia, hemorrhage, degeneration and necrosis on the test side of the rabbit's ear vein, and no pathological damage, indicating that the compound injection of the present invention The intravenous infusion of the solution did not cause irritation to the blood vessels of the rabbit ears, and the inspection was in compliance with the regulations.

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Abstract

The invention relates to a compound injection containing 18 amino acids and a preparation method thereof, and in particular relates to a compound high branched-chain amino acid injection and a preparation method thereof. The preparation method comprises the step of dissolving different amino acids at different temperatures by adopting an amino acid multi-step feeding method, so that the stability of an amino acid raw material can be improved, and the stability of the injection finished product quality can be guaranteed.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a compound injection containing 18 kinds of amino acids and a preparation method thereof. Background technique [0002] Amino acid is the basic unit of protein molecules in organisms. It is closely related to the life activities of organisms. It is one of the indispensable nutrients in organisms. The digestion and absorption of protein in the body is completed through amino acids. The need is actually the need for amino acids, which play a role in maintaining nitrogen balance in the process of protein synthesis and decomposition. Hypoproteinemia is the result of negative nitrogen balance caused by various reasons. The main causes are: insufficient protein intake or malabsorption, loss of appetite and anorexia caused by various reasons; Hepatic protein synthesis ability is reduced, plasma protein synthesis is reduced; long-term large amount of protein loss; protein d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4172A61K31/401A61K31/198A61K9/08A61P3/02
Inventor 郑伟
Owner 沈阳海思科制药有限公司