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Eye drops for treating uveitis and preparation method thereof

A technology for uveitis and eye drops, which is applied in the field of traditional Chinese medicine, can solve the problems of poor patient compliance and unobvious curative effect of uveitis, and achieve the effects of reducing recurrence rate, improving cure rate, and high medication compliance

Active Publication Date: 2014-12-03
山东施尔明眼科医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention proposes an eye drop for treating uveitis, which solves the problem that the existing traditional Chinese medicine has no obvious curative effect on uveitis and poor patient compliance, and it can improve the cure rate and reduce the recurrence rate when used in combination with western medicine.

Method used

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  • Eye drops for treating uveitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] 1) 1 weight part of cholic acid, 1 weight part of baicalin, 2 weight parts of gardenia extract, 0.01 weight part of borneol, and 0.3 weight part of xuanming powder are mixed evenly;

[0076] 2) Add the above homogeneously mixed mixture to one or any of several solutions of thickeners, osmotic pressure regulators, bacteriostatic agents or pH regulators or add thickeners, osmotic pressure regulators, bacteriostatic Add one or any of several agents or pH regulators to the uniformly mixed mixture solution to obtain the ophthalmic solution for treating uveitis.

[0077] The thickener is one or more of sodium hyaluronate, carbomer, sodium carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, chitosan, hyaluronic acid, hypromellose, etc. Any mixture of several.

[0078] The osmotic pressure regulator is one or a mixture of any of sodium chloride, potassium chloride, glucose, borax, boric acid, mannitol and glycerin.

[0079] The antibacterial agent is one or a mixt...

Embodiment 2

[0082] 1) Mix 3 parts by weight of cholic acid, 3 parts by weight of baicalin, 5 parts by weight of gardenia extract, 0.06 parts by weight of borneol, and 0.7 parts by weight of xuanming powder;

[0083] 2) Add one or more of a thickener, an osmotic pressure regulator, a bacteriostat or a pH regulator to the homogeneously mixed mixture to obtain the eye drops for treating uveitis.

[0084] The thickener is one or more of sodium hyaluronate, carbomer, sodium carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, chitosan, hyaluronic acid, hypromellose, etc. Any mixture of several.

[0085] The osmotic pressure regulator is one or a mixture of any of sodium chloride, potassium chloride, glucose, borax, boric acid, mannitol and glycerin.

[0086] The antibacterial agent is one or a mixture of any of ethyl paraben, ethyl p-hydroxyformate, phenoxyethanol, parabens, sorbic acid, and chlorobutanol.

[0087] The pH regulator is one or any combination of borax, boric acid, s...

Embodiment 3

[0089] 1) Mix 4 parts by weight of cholic acid, 4 parts by weight of baicalin, 7 parts by weight of gardenia extract, 0.1 part by weight of borneol, and 0.3 to 1.2 parts by weight of xuanming powder;

[0090] 2) Add the above homogeneously mixed mixture to one or any of several solutions of thickeners, osmotic pressure regulators, bacteriostatic agents or pH regulators or add thickeners, osmotic pressure regulators, bacteriostatic Add one or any of several agents or pH regulators to the uniformly mixed mixture solution to obtain the ophthalmic solution for treating uveitis.

[0091] The thickener is one or more of sodium hyaluronate, carbomer, sodium carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, chitosan, hyaluronic acid, hypromellose, etc. Any mixture of several.

[0092] The osmotic pressure regulator is one or a mixture of any of sodium chloride, potassium chloride, glucose, borax, boric acid, mannitol and glycerin.

[0093] The antibacterial agent is on...

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Abstract

The invention discloses eye drops for treating uveitis and a preparation method thereof. The eye drops for treating uveitis comprise the following components in parts by weight: 1-4 parts of cholic acid, 1-4 parts of baicalin, 2-7 parts of gardenia extract, 0.01-0.1 part of borneol and 0.3-1.2 parts of mirabilitum dehydratum, and further comprises one or more of thickening agent, osmotic pressure regulator, bacteriostat or pH regulator. The invention provides a medicine preparation which is safe, efficient and convenient to use, or a modern traditional Chinese medicine compound eye-drops preparation which has good stability, less adverse reactions and high medication compliance for clinical treatment of the uveitis, and solves the problems that the existing pure traditional Chinese medicine or western medicine has an un-remarkable curative effect for treating the uveitis, a large side effect and a high recurrence rate.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to an eye drop for treating uveitis and a preparation method thereof. Background technique [0002] Uveitis is a common blinding eye disease that seriously endangers visual health and mostly occurs in young adults and children. Most of the blindness caused by it is incurable, which has caused a serious burden to society and families. At present, western medicine mainly treats with hormones and immunosuppressants, which have serious side effects, are prone to recurrence and chronicity, and can lead to multiple complications such as secondary glaucoma, concurrent cataract, and optic nerve damage. Uveitis belongs to the categories of "tight and small pupils", "short pupils", and "dimmed vision" in traditional Chinese medicine. More than 3 million compatriots in my country suffer from this disease, and it has a continuous upward trend. Due to uveitis Factors such as...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/744A61K9/08A61P27/02A61K33/04A61K31/7048A61K31/045A61K31/575
Inventor 毕宏生郭俊国崔彦解孝锋
Owner 山东施尔明眼科医院