Production process of medicinal potassium citrate

The technology of potassium citrate and citrate ammonium salt is applied in the field of medicine and chemical industry, can solve the problem of low yield and the like, and achieve the effects of easy availability of raw materials, high production safety and high purity

Active Publication Date: 2013-04-03
HUNAN ER KANG PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The present invention proposes an improved method for producing potassium citrate to overcome the low yield problem in the prior art

Method used

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  • Production process of medicinal potassium citrate

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Embodiment 1

[0041] 1. Weigh 5 kg of ammonium citrate salt, add 35 L of purified water, stir and raise the temperature to dissolve, and control the temperature at 50 °C to obtain triammonium citrate salt solution.

[0042] 2. Take the ammonium citrate solution and pass it through the HP-20 macroporous adsorption resin column. After the column is loaded, add water to fully elute to remove other impurities, and then use 31L of potassium carbonate solution with a concentration of 1.0% to elute , collect the eluate, concentrate under reduced pressure to 10L, and obtain potassium citrate concentrate.

[0043] 3. Take the concentrated solution, dilute it with water, add 20g of activated carbon, absorb, decolorize, and keep warm for 50 minutes. Connect the suction filtration device, and filter out activated carbon and trace impurities remaining in the solution through a coarse filtration (1 um) filter membrane. Then perform fine filtration (0.45um) and ultrafiltration (0.22um), and collect the f...

Embodiment 2

[0048] 1. Weigh 10kg of citric acid, add 70L of purified water, stir and heat up to dissolve, and control the temperature at 50°C to obtain a triammonium citrate solution.

[0049] 2. Take the triammonium citrate solution and pass it through the ion exchange resin column of model D301. After the column is loaded, add water to fully elute to remove other impurities, and then use 130L of potassium hydroxide solution with a concentration of 0.5% to elute. The eluate was collected and concentrated under reduced pressure to 18 L to obtain a concentrated solution of tripotassium citrate.

[0050] 3. Take the concentrated solution, add water to dilute appropriately, add 60g of activated carbon, absorb, decolorize, and keep warm for 70 minutes. Connect the suction filtration device, and filter out activated carbon and trace impurities remaining in the solution through a coarse filtration (1 um) filter membrane. Then perform fine filtration (0.45um) and ultrafiltration (0.22um), and c...

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Abstract

The invention discloses a production process of potassium citrate and belongs to the field of medicine chemical. The preparation method essentially consists of dissolving, column separation, ion substitution, decolorization, filtration and crystallization. The method has the characteristics that raw materials are available, reaction condition is mild, operation is convenient, pollution is little, and the like, and is favorable for the industrial production. Purity of the medicinal potassium citrate produced by the process disclosed by the invention can reach greater than 99% (high performance liquid chromatography (HPLC) method).

Description

technical field [0001] The invention provides a production process of medicinal potassium citrate, which belongs to the field of medicine and chemical industry. Background technique [0002] Potassium citrate is also known as potassium citrate or tripotassium citrate. Potassium citrate crystal is 2-hydroxypropane-1,2,3-tricarboxylic acid tripotassium monohydrate, that is, tripotassium citrate monohydrate , is a colorless crystal or white crystalline powder, used as an alkaline potassium salt in the pharmaceutical industry, used for hypokalemia and alkaline urine. The existing industrial preparation method of potassium citrate crystals is to react citric acid with potassium hydroxide or potassium carbonate, concentrate the reaction solution and obtain potassium citrate dihydrate crystals by crystallization. [0003] Tripotassium citrate monohydrate is also known as potassium citrate monohydrate, and its structural formula is as follows: [0004] [0005] The traditional ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C59/265C07C51/41
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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