Extraction separation method of rosmarinic acid in salvia castabea diels f. tomentosa stib
A separation method, rosmarinic acid technology, applied in the separation/purification of carboxylic acid esters, chemical instruments and methods, preparation of carboxylic acid esters, etc., can solve high production costs, rosmarinic acid recovery rate and low content , low production cost and other issues
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Embodiment 1
[0070] Grind 50 kg of Tibetan Salvia miltiorrhiza (3.2% rosmarinic acid) into 40 meshes, add 400 kg of 75% ethanol and use a multi-functional ultrasonic extraction tank for ultrasonic extraction at 40°C for 1 hour, extract once more according to the above method, and combine twice The extract is concentrated under reduced pressure below 50°C until there is no ethanol, and 500 kg of purified water is added to obtain an aqueous solution of Tibetan miltiorrhiza extract; the solution is filtered and clarified by ultrafiltration equipment to obtain a clear solution of Tibetan miltiorrhiza extract; filter equipment to obtain nanofiltration solution; the nanofiltration solution is adjusted to PH=4 with dilute hydrochloric acid, adsorbed on polyamide resin, washed with purified water to remove impurities, and 50% ethanol elutes rosmarinic acid; contains rosmarinic acid components The eluent was concentrated with a reverse osmosis membrane, and the concentrated solution was spray-dried ...
Embodiment 2
[0072] Grind 50 kg of Tibetan Salvia (3.2% rosmarinic acid) into 80 meshes, add 500 kg of 70% ethanol and use a multi-functional ultrasonic extraction tank for ultrasonic extraction at 20°C for 1 hour, extract once more according to the above method, and combine twice The extract is concentrated under reduced pressure below 50°C to no ethanol, and 500 kg of purified water is added to obtain an aqueous solution of the extract of Tibetan Salvia miltiorrhiza; the solution is filtered and clarified by an ultrafiltration device to obtain a clear solution of the extract of Tibetan salvia filter equipment to obtain nanofiltration solution; the nanofiltrate is adjusted to PH=2 with dilute hydrochloric acid, adsorbed on polyamide resin, washed with purified water to remove impurities, and 80% ethanol elutes rosmarinic acid; contains rosmarinic acid components The eluent was concentrated with a reverse osmosis membrane, and the concentrated solution was spray-dried to obtain 1.65 kg of r...
Embodiment 3
[0074] Crush 50 kg of Tibetan Salvia miltiorrhiza (3.2% rosmarinic acid) into 20 meshes, add 450 kg of 95% ethanol and use a multi-functional ultrasonic extraction tank to extract ultrasonically at 60°C for 1 hour, extract once more according to the above method, and combine twice The extract is concentrated under reduced pressure below 50°C to no ethanol, and 500 kg of purified water is added to obtain an aqueous solution of the extract of Tibetan Salvia miltiorrhiza; the solution is filtered and clarified by an ultrafiltration device to obtain a clear solution of the extract of Tibetan salvia Filtration equipment is used to filter to obtain nanofiltration solution; the nanofiltration solution is adjusted to PH=3 with dilute hydrochloric acid, adsorbed on polyamide resin, washed with purified water to remove impurities, and 90% ethanol elutes rosmarinic acid; contains rosmarinic acid components The eluent was concentrated with a reverse osmosis membrane, and the concentrated s...
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Abstract
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