Extraction separation method of rosmarinic acid in salvia castabea diels f. tomentosa stib
A technology of rosmarinic acid and separation method, which is applied in the separation/purification of carboxylate, chemical instruments and methods, preparation of carboxylate, etc., can solve the problem of low production cost, waste of resources, rosmarinic acid recovery rate and The problem of low content
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Embodiment 1
[0070] Grind 50 kg of Tibetan Salvia miltiorrhiza (3.2% rosmarinic acid) into 40 meshes, add 400 kg of 75% ethanol and use a multi-functional ultrasonic extraction tank for ultrasonic extraction at 40°C for 1 hour, extract once more according to the above method, and combine twice The extract is concentrated under reduced pressure below 50°C until there is no ethanol, and 500 kg of purified water is added to obtain an aqueous solution of Tibetan miltiorrhiza extract; the solution is filtered and clarified by ultrafiltration equipment to obtain a clear solution of Tibetan miltiorrhiza extract; filter equipment to obtain nanofiltration solution; the nanofiltration solution is adjusted to PH=4 with dilute hydrochloric acid, adsorbed on polyamide resin, washed with purified water to remove impurities, and 50% ethanol elutes rosmarinic acid; contains rosmarinic acid components The eluent was concentrated with a reverse osmosis membrane, and the concentrated solution was spray-dried ...
Embodiment 2
[0072] Grind 50 kg of Tibetan Salvia miltiorrhiza (3.2% rosmarinic acid) into 80 meshes, add 500 kg of 70% ethanol and use a multifunctional ultrasonic extraction tank for ultrasonic extraction at 20°C for 1 hour, extract once more according to the above method, and combine twice The extract is concentrated under reduced pressure below 50°C until there is no ethanol, and 500 kg of purified water is added to obtain an aqueous solution of Tibetan miltiorrhiza extract; the solution is filtered and clarified by ultrafiltration equipment to obtain a clear solution of Tibetan miltiorrhiza extract; filter equipment to obtain nanofiltration solution; the nanofiltration solution is adjusted to PH=2 with dilute hydrochloric acid, adsorbed on polyamide resin, washed with purified water to remove impurities, and 80% ethanol elutes rosmarinic acid; contains rosmarinic acid components The eluent was concentrated with a reverse osmosis membrane, and the concentrated solution was spray-dried t...
Embodiment 3
[0074] Crush 50 kg of Tibetan Salvia miltiorrhiza (3.2% rosmarinic acid) into 20 meshes, add 450 kg of 95% ethanol and use a multifunctional ultrasonic extraction tank to extract ultrasonically at 60°C for 1 hour, extract once more according to the above method, and combine twice The extract is concentrated under reduced pressure below 50°C until there is no ethanol, and 500 kg of purified water is added to obtain an aqueous solution of Tibetan miltiorrhiza extract; the solution is filtered and clarified by ultrafiltration equipment to obtain a clear solution of Tibetan miltiorrhiza extract; filter equipment to obtain nanofiltration solution; the nanofiltration solution is adjusted to PH=3 with dilute hydrochloric acid, adsorbed on polyamide resin, washed with purified water to remove impurities, and 90% ethanol elutes rosmarinic acid; contains rosmarinic acid components The eluent was concentrated with a reverse osmosis membrane, and the concentrated solution was spray-dried t...
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