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Rhodiola extract and pharmaceutical composition thereof as well as application of rhodiola extract in treatment of fatty liver disease

A technology of Rhodiola rosea and its extract, which is applied in the field of medicine, can solve the problems of no effective drugs for preventing and treating fatty liver, and achieve the effects of improving liver microcirculation disorder, low production cost, and reducing liver fat content

Inactive Publication Date: 2013-04-24
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there is no effective drug for the prevention and treatment of fatty liver in Western medicine, mostly symptomatic treatment, such as vitamin B, C, E, lecithin, ursodeoxycholic acid, silymarin, inosine, coenzyme A, reduced glutathione Glycerin, taurine, carnitine orotate, etc. protect liver cells, antioxidants, and lipid-lowering drugs such as bifendate

Method used

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  • Rhodiola extract and pharmaceutical composition thereof as well as application of rhodiola extract in treatment of fatty liver disease
  • Rhodiola extract and pharmaceutical composition thereof as well as application of rhodiola extract in treatment of fatty liver disease
  • Rhodiola extract and pharmaceutical composition thereof as well as application of rhodiola extract in treatment of fatty liver disease

Examples

Experimental program
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Effect test

Embodiment 1

[0056] Adopt the dried Rhodiola rosea rhizome as the original drug, grind it and extract it 3 times with 80% ethanol under reflux, each dosage is 8 times of the weight of the original drug, and the extraction time is 2 hours each time, the extracts are combined and filtered, and the filtrate Concentrate under reduced pressure to recover ethanol until there is no alcohol smell, and obtain the extract, adjust the density of the extract to 1.16, add 5 times the amount of water to carry out water precipitation, stand at 5°C for 72 hours, filter the precipitate, concentrate the filtrate under reduced pressure, and perform HP -20 macroporous adsorption resin separation, using three gradients of pure water, 50% ethanol, and 95% ethanol for elution, concentrating the eluent of 50% ethanol under reduced pressure, and obtaining the effective part of Rhodiola rosea after freeze-drying .

Embodiment 2

[0058] Adopt the dry rhizome of Rhodiola angustifolia as the original drug, grind and extract 2 times with 95% ethanol backflow, each dosage is 7 times of the weight of the original drug, and the extraction time is 3 hours each time, the extracts are combined and filtered, and the filtrate is reduced Concentrate under pressure to recover ethanol until there is no alcohol smell, and obtain the extract, adjust the density of the extract to 1.18, add 8 times the amount of water to carry out water precipitation, stand at 5°C for 96 hours, filter the precipitate, and perform HP- Separation with 40 macroporous adsorption resins, using four gradients of pure water, 5% ethanol, 50% ethanol, and 95% ethanol for elution, concentrating the eluent of 50% ethanol under reduced pressure, and obtaining Rhodiola angustifolia after freeze-drying effective part.

Embodiment 3

[0060] Adopt dry Rhodiola rosea rhizome as the original drug, crush it and extract it twice with 70% methanol under reflux, each dosage is 8 times the weight of the original drug, and the extraction time is 2 hours each time, the extracts are combined and filtered, and the filtrate Concentrate under reduced pressure to recover methanol to obtain an extract, adjust the density of the extract to 1.17, add 6 times the amount of water for water precipitation, stand at 5°C for 48 hours, filter the precipitate, and concentrate the filtrate under reduced pressure for D101 macroporous adsorption resin The separation is carried out by four gradients of pure water, 5% ethanol, 50% ethanol and 95% ethanol for elution, the eluate of 50% ethanol is concentrated under reduced pressure, and the effective fraction of Rhodiola rosea is obtained after freeze-drying.

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Abstract

The invention discloses a rhodiola extract and a pharmaceutical composition thereof and application of the rhodiola extract in treatment of a fatty liver disease. A preparation method for an effective part of rhodiola is characterized by comprising the following steps of: (A) crushing dry rhizomes of a rhodiola plant, performing extraction by using an organic solvent, and recovering the solvent from the extraction liquid under reduced pressure to obtain an extract; adjusting the extract to a proper density, performing water deposition in pure water, filtering the sediment, and concentrating the filtrate under reduced pressure to obtain a total rhodiola extract; and (B) separating the total rhodiola extract by using macromolecular adsorption resin, performing gradient elution by using a water or ethanol system, concentrating the eluent under reduced pressure, performing freeze drying, thus obtaining the effective part of the rhodiola.

Description

technical field [0001] The invention relates to a rhodiola rosea extract isolated from plants of the genus Rhodiola and the application of the pharmaceutical composition thereof in the preparation of medicines and health care products for treating fatty liver disease, belonging to the field of medicine. Background technique [0002] The Rhodiola plant is a plant of the genus Rhodiola (Crassulaceae) in the Crassulaceae family. It has a long history of medicinal use and is named "Soroma Treasure" in Tibet. "Jingzhu Materia Medica" records that the effects of Rhodiola are to nourish the lungs, clear away heat, and nourish vitality. Rhodiola rosea is commonly used in Tibetan folks to treat hemoptysis, hemoptysis, pneumonia cough and women's leucorrhea embolism. "Shen Nong's Materia Medica" records that Rhodiola has a lot of hot burns, body troubles and evil spirits, insects and poisonous scabs, cold and heat wind numbness, various deficient flowers, the hostess leaked red and w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/41A23L1/29A61P1/16A23L33/00
Inventor 叶菲张培成田金英杨桠楠张晓琳冯子明李娟姜建双陈玲杨晓萌付健阳王丽韩静
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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