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Method for surface-enhanced Raman scattering spectrum detection by using silver-surface molecularly imprinted polymer

A technology of surface molecular imprinting and surface-enhanced Raman, which is applied in Raman scattering, material excitation analysis, etc., can solve the problems of affecting the detection effect, complex methods, poor combination of molecular imprinting and metal film, etc., and achieve high extraction efficiency, High sensitivity, avoiding the effect of poor binding

Active Publication Date: 2013-04-24
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The present invention is to solve the problem that the existing methods need to mix the molecularly imprinted polymer with other substances such as silver colloid or coat the molecularly imprinted polymer on other metal films such as silver. The method is complicated and there are molecularly imprinted substances and metal films In order to solve the problem of poor combination of silver and affect the detection effect, a method for surface-enhanced Raman scattering detection using molecularly imprinted polymers on the silver surface is provided.

Method used

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  • Method for surface-enhanced Raman scattering spectrum detection by using silver-surface molecularly imprinted polymer
  • Method for surface-enhanced Raman scattering spectrum detection by using silver-surface molecularly imprinted polymer
  • Method for surface-enhanced Raman scattering spectrum detection by using silver-surface molecularly imprinted polymer

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specific Embodiment approach 1

[0018] Specific embodiment 1: In this embodiment, the method for surface-enhanced Raman scattering detection using molecularly imprinted polymers on the silver surface is carried out according to the following steps: 1. Prepare 500nm-5μm silver particles: a. Prepare 5-10mL with a concentration of 1mol / L AgNO 3 solution, 20-35mL of ascorbic acid solution with a concentration of 1mol / L, 1-5mL of citric acid b with a concentration of 0.35mol / L, and 1-2g of polyvinylpyrrolidone dissolved in 3-8mL of distilled water to obtain a polyvinylpyrrolidone solution ; c. Put the container into an ice-water bath, add 60 to 100 mL of distilled water and the AgNO prepared in step a to the container. 3 Solution, the citric acid prepared in step a and the polyvinylpyrrolidone solution in step b are mixed, then, under stirring, add the ascorbic acid solution prepared in step a, react for 15-30min, carry out centrifugation, take the solid phase, and wash with distilled water for 2- 4 times, then...

specific Embodiment approach 2

[0026] Embodiment 2: This embodiment is different from Embodiment 1 in that: the drying in step c is to dry in a vacuum oven at 40°C for 12 hours. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0027] Embodiment 3: This embodiment is different from Embodiment 1 in that the double bond silane reagent in step 2 is methacryloxypropyltrimethoxysilane. Others are the same as in the first embodiment.

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Abstract

The invention provides a method for surface-enhanced Raman scattering spectrum detection by using a silver-surface molecularly imprinted polymer, and relates to the method for the surface-enhanced Raman scattering spectrum detection by using a molecularly imprinted polymer. The invention aims at solving intricate process and poor detection effect problems caused by poor combination between the molecularly imprinted polymer and a metal film in an existing method which needs to mix the molecularly imprinted polymer and other substances such as silver colloid or coat the molecularly imprinted polymer on other metal films such as a silver film. The method provided by the invention comprises the following steps of: I preparing silver particles of 500 nanometers to 5 microns; II, modifying the surface of the silver particles; III, preparing pre-assembled solution of target molecules and functional monomers; IV, preparing pre-polymerized solution of the molecularly imprinted polymer of the silver; V, preparing the particles of silver-core molecularly imprinted membrane shells; VI, preparing the silver-surface molecularly imprinted polymer; and VII, performing the Raman detection. The method provided by the invention is applied to the field such as clinical medicine analysis, quantitative analysis, trace analysis and single-molecule level.

Description

technical field [0001] The invention relates to a method for surface-enhanced Raman scattering spectrum detection using molecularly imprinted polymers. Background technique [0002] Molecularly imprinted polymers have the advantages of high affinity and selectivity, strong resistance to harsh environments, high stability and long service life. Therefore, they are used in many fields such as enantiomer separation in chromatographic analysis and clinical drug analysis. , chemical biomimetic sensors, simulated enzyme catalysis, membrane separation and solid phase extraction and other fields have shown good application prospects. The surface-enhanced Raman scattering (SERS) technology enhances the energy transfer between the substrate and the molecule, avoids the interference of the fluorescent background, increases the scattering area of ​​the sample, thereby enhancing the signal of the sample, and making the detection accuracy of Raman scattering spectroscopy more accurate. t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
Inventor 李欣丁燕常立民
Owner HARBIN INST OF TECH
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