Electrode for trans-scale glucose biosensor based on ZnO nanowire and preparation method thereof

Abstract

The invention relates to an electrode for a trans-scale glucose biosensor based on a ZnO nanowire and a preparation method thereof. The electrode comprises an optical fiber core taken as a substrate and a gold bonding wire wound on the optical fiber core in a manner of a spiral line; wherein the gold bonding wire is divided into a spiral line part and a lead part; the ZnO nanowire grows in the direction of a spiral line surface normal of the spiral line part by adopting a hydrothermal method; and glucose oxidase is fixed on the ZnO nanowire. The electrode and the preparation method thereof have the benefits that the gold bonding wire is wound on the cylindrical optical fiber core to form a spiral line array structure; secondly, the ZnO nanowire grows at the spiral line part of the gold bonding wire based on a water bath method to form a micro-nanometer trans-scale structure for increasing the adsorption area of the glucose oxidase; and based on the trans-scale structure, the process parameters of the ZnO nanowire are improved to form a specific random rough surface for enhancing the adsorption of buffer solution on the spiral line-shaped electrode and the fixation of the glucose oxidase on the electrode, thereby greatly improving the catalytic efficiency of the electrode for a glucose sensor.

Description

technical field [0001] The invention belongs to the field of micro-sensing technology, and is mainly used in the fields of medicine, biology, food processing, electrochemistry, environmental monitoring, etc., and particularly relates to a ZnO nanowire-based cross-scale sensor for detecting glucose concentration in human blood and urine. An electrode for a glucose sensor and a preparation method thereof. Background technique [0002] Glucose is a very critical metabolite for living organisms. For diabetic patients, accurate and rapid determination of glucose concentration in blood and urine has always been a very important clinical testing item. At present, the third-generation glucose sensor, which is mainly characterized by direct electron transfer between glucose oxidase and the sensor electrode, is receiving more and more attention. The research focus mainly includes the chemical reaction mechanism between glucose oxidase and the measured glucose. 1. Material selection ...

AI Technical Summary

Problems solved by technology

However, due to the planar structure of the electrode used in this type of glucose sensor, the size of the structure is large, it is not easy to miniaturize, and the increase in the adsorption area of ​​the electrode is not significant; in addition, a layer of gold film must be sputtered on the planar substrate as the electrode. The preparation environment has high requirements, so it is not suitable to control the production cost

Images