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Micro-fluidic chip-based pH (Potential of Hydrogen) response micro valve and preparation method thereof

A microfluidic chip and microvalve technology is applied in chemical instruments and methods, processes for producing decorative surface effects, valve devices, etc. Good application prospect, cost reduction, simple operation effect

Inactive Publication Date: 2013-05-01
SUZHOU WENHAO MICROFLUIDIC TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In terms of microvalve research, it is divided into active and passive valves according to whether there is a power drive mechanism. This type of microvalve can realize the opening / closing of the valve, has good braking performance and high airtightness, but the disadvantage is that the structure is complex, the volume is large, and it is difficult to realize the integration on the chip.
Passive valves do not require external dynamic braking, and rely on the pressure difference on both sides of the valve to realize the switch. Its volume is small, but it cannot actively open / close or switch the valve
[0004] However, it is difficult for conventional technologies to intelligently drive and control microfluidics in microchannels. Therefore, by controlling changes in pH to control changes in surface wettability to drive and control microfluidics in microfluidic chips, the development of a Convenient, fast, efficient, and low-cost microfluidic drive and control technology should be one of the research directions for microvalve on microfluidic chips, and there has been no substantial breakthrough yet

Method used

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  • Micro-fluidic chip-based pH (Potential of Hydrogen) response micro valve and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The microstructure and microchannel pattern of the two-layer chip of the microfluidic chip with controllable microfluidic flow are designed and drawn by computer-aided design software. The microstructure and microchannel of the two-layer polymethyl methacrylate (PMMA) chip were processed and prepared by the numerical control CNC system. The chips of each layer were cleaned with tap water and distilled water respectively, and the remaining fingerprints, oil stains and other stains on the surface of the chip were wiped with ethanol. On the double-sided adhesive film, the required microstructures and microchannels were processed with a cutting machine. The two-layer chip is carefully aligned, glued, and pressure-sealed to make a smart microvalve based on a microfluidic chip. Add the sample solution into the injection hole of the microfluidic chip, and the solution enters the microchannel driven by the external peristaltic pump. In the microvalve area of ​​the microchannel,...

Embodiment 2

[0024] The microstructure and microchannel graphics of the two-layer chip of the centrifugal microfluidic chip were designed and drawn by computer-aided design software. The microstructure and microchannel of the two-layer disc-shaped polycarbonate (PC) chip were processed and prepared by the numerical control CNC system. The chips of each layer were cleaned with tap water and distilled water respectively, and the remaining fingerprints, oil stains and other stains on the surface of the chip were wiped with ethanol. On the double-sided adhesive film, the required microstructures and microchannels were processed with a cutting machine. The two-layer chip is carefully aligned, glued, and pressure-sealed to make a smart microvalve based on a microfluidic chip. Add the sample solution into the injection hole of the microfluidic chip, and the solution enters the microchannel driven by the external peristaltic pump. In the microvalve area of ​​the microchannel, the surface responds ...

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Abstract

The invention relates to a micro-fluidic chip-based pH (Potential of Hydrogen) response micro valve and a preparation method thereof. A micro-structure and a micro-passage are arranged on the surface of a micro-fluidic chip; the main micro-passage is provided with a hydrophilic / hydrophobic gate controlled switch; the surface of the micro-passage is modified through pH responsive molecules; change in surface wettability is caused by reversible changes of surface topography and chemical configuration of the micro-passage under stimulation of different pHs; and motion of micro-fluid on the surface of the micro-passage is controlled, so that an intelligent micro-valve for controlling the flow of micro-fluid is realized. The valve is mainly applied to the related fields such as electrophoretic separation, chromatographic separation and immunoassay. The micro-fluidic chip realizes intelligent driving and control of the micro-fluid, the micro-fluid driving and control cost is greatly reduced, the valve has the characteristics of portability, economy, quickness and high efficiency, and a completely new analysis technology is provided for micro-fluid driving and control.

Description

technical field [0001] The invention relates to a pH response microvalve based on a microfluidic chip and a preparation method thereof. The surface of the microfluidic chip has microstructures and microchannels, and the main microchannel is provided with a hydrophilic / hydrophobic gating switch. Molecules modify the surface of the microchannel. Under the stimulus of different pH, the reversible change of the surface morphology and chemical configuration of the microchannel leads to the change of the surface wettability, which controls the movement of the liquid fluid on the surface of the microchannel, thereby realizing the microchannel The intelligent microvalve for fluid flow control is mainly used in electrophoretic separation, chromatographic separation, immunoassay and other related fields. Background technique [0002] As a new type of analysis platform, microfluidic analysis chip has the advantages of miniaturization, automation, integration, convenience and speed, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): F16K99/00B81C1/00B01L3/00
Inventor 聂富强沙俊王晓东叶嘉明
Owner SUZHOU WENHAO MICROFLUIDIC TECH CO LTD
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