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Doxycycline soluble powder and preparation method thereof

A doxycycline, soluble technology, applied in the direction of powder delivery, active ingredients of tetracycline, and devices for making drugs into special physical or taking forms, etc., can solve problems such as difficult to mix uniformly, drug sedimentation, low dose, etc., to achieve The preparation process is simple and easy, reducing the labor burden and increasing the solubility

Inactive Publication Date: 2013-05-08
QINGDAO VLAND BIOTECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main problem with this type of product is that after mixing with drinking water, due to the extremely low solubility of doxycycline, the drug will settle, causing chickens to not be able to drink enough of the drug; Low, it is difficult to mix evenly, which will inevitably affect the effect of anticoccidial

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Weigh 800g of polyethylene glycol 4000 and heat to 80°C, stir until completely melted, add methanol solution containing 200g of doxycycline, stir until evenly dispersed, heat to remove methanol, cool to 0°C to make it completely solidified, and dry the mixture After crushing and passing through an 80-mesh sieve, the soluble powder of doxycycline can be obtained.

Embodiment 2

[0015] Weigh 600g of polyethylene glycol 6000 and heat to 100°C, stir until completely melted, add 100g of doxycycline in methanol solution, stir until evenly dispersed, heat to remove methanol, cool to 0°C to make it completely solidified, and dry the mixture Crush through a 60-mesh sieve, and pack separately to obtain doxycycline soluble powder.

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PUM

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Abstract

The invention relates to a doxycycline soluble powder and a preparation method thereof. The method uses a solid dispersing technology, and comprises heating a solid dispersion carrier to 80-100 DEG C into a molten state, adding a methanol solution of the doxycycline, stirring, mixing uniformly, steaming to remove the methanol, cooling, crushing, and sieving to obtain the finish product. According to the invention, a solubility of the doxycycline is improved, the preparation technology is simple and the cost is low.

Description

technical field [0001] The invention relates to doxycycline soluble powder and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] Doxycycline is an antibiotic drug, tetracycline drug, which can treat chlamydia mycoplasma infection. Its properties are light yellow or yellow crystalline powder, smelly and bitter. Soluble in water or methanol, slightly soluble in ethanol or acetone, insoluble in chloroform. It is mainly used for the treatment of respiratory, urinary tract and biliary tract infections caused by sensitive bacteria. The antibacterial spectrum is basically the same as that of tetracycline and oxytetracycline, and its antibacterial activity in vivo and in vitro is stronger than that of tetracycline. Microorganisms have close cross-resistance to this product and tetracycline, oxytetracycline, etc. Oral absorption is good. It is mainly used for upper respiratory tract infection, flat strip inflammatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/65A61P31/04A61J3/02
Inventor 林扬郝智慧王艳玲
Owner QINGDAO VLAND BIOTECH INC