Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Compound sodium chloride eye drops

A technology of compound sodium chloride and eye drops, which is applied in the direction of active ingredients of alkali/alkaline earth metal chlorides, pharmaceutical formulas, inorganic active ingredients, etc. It can solve the problem of short retention time of artificial tears, difficulty in providing corneal oxygen, and lipids on the ocular surface. To protect the eyes, alleviate and treat dry eye syndrome, and improve the patient's symptoms

Inactive Publication Date: 2013-05-08
SUZHOU BEAUTY OF TAIHU LAKE MEDICINE
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the residence time of artificial tears known in the prior art on the cornea is relatively short
Therefore, it is necessary to apply the artificial tear treatment agent at regular intervals on the eyes as the case may be, which is too cumbersome and uncomfortable for the patient. Some gel-like therapeutic agents are difficult to provide sufficient oxygen to the cornea. In addition, the osmotic pressure, pH value, viscosity, and electrolyte concentration of existing artificial tears are different from those of human tears. Use will lead to the loss or destruction of the lipid layer of the ocular surface, which may further aggravate "dry eye patients with abnormal lipid layer"

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The formula and / configuration process of a certain ratio relation of compound sodium chloride eye drops of the present invention:

[0017] Prepare the compound sodium chloride eye drops with a volume of 340L, and the mass of each component is 3.06Kg sodium chloride + 0.0476kg potassium chloride + 0.068kg sodium bicarbonate + 1.02kg hydroxypropyl methylcellulose + 0.102kg paraben Dissolve the sodium chloride, potassium chloride and ethylparaben ester in the appropriate amount of hot water for injection by weighing the prescription amount. After the dissolution is complete, add hydroxypropylmethylcellulose, stir under heating to make it completely hydrated, and wait for After it is completely dissolved, filter and add water for injection to a sufficient amount, adjust the pH value between 6.5 and 8.5 with sodium bicarbonate solution, pack separately, and sterilize repeatedly at low temperature intermittently to obtain the finished product. According to the standard of "Ch...

Embodiment 2

[0019] The compound sodium chloride eye drops of the present invention does not add the formula of antiseptic and / configuration process:

[0020] The preparation volume is the compound sodium chloride eye drops of 75L, and each component mass is 765g sodium chloride+11.9g potassium chloride+17g sodium bicarbonate+255g hydroxypropyl methylcellulose, takes the sodium chloride of prescription quantity 1. Potassium chloride is dissolved in an appropriate amount of hot water for injection. After the dissolution is complete, add hydroxypropyl methylcellulose, stir under heating to make it fully hydrated, and after it is completely dissolved, filter and add water for injection to a sufficient amount, hydrogen carbonate The sodium solution adjusts the pH value between 6.5 and 8.5, packs in separate packages, sterilizes repeatedly at low temperature intermittently, and then seals the package to obtain the finished product. According to the standard of "Chinese Pharmacopoeia", the resul...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses compound sodium chloride eye drops comprising the components of: sodium chloride, potassium chloride, sodium bicarbonate, hydroxypropylmethyl cellulose, an antiseptic of ethylparaben, and a solvent of water. According to the compound sodium chloride eye drops provided by the invention, a proper amount of hydroxypropylmethyl cellulose is used for regulating the viscosity, and ethylparaben is adopted as the antiseptic, such that the viscosity is appropriate, and a preservative effect is stable. The eye drops have properties similar to those of human body's own tear secretion. With the eye drops, moisture can be supplemented for eyes, eye surface can be moisturized, and a mucinous water-absorbent solution is formed and covered on the surface of eyes, such that eyes can be protected, and patient symptoms can be ameliorated. The eye drops can be used for effectively relieving and treating xerophthalmia.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to an artificial tear, in particular to a compound sodium chloride eye drop. Background technique [0002] Tears are an innate protective mechanism of human beings. It contains lysozyme to reduce the damage of infection or other harmful substances on the surface of the eyeball to a certain extent. In addition, it can keep the corneal surface smooth and produce clear vision, and form a thin tear film on the corneal epithelium to continuously moisten and lubricate the eyeball, making the eyes feel comfortable. [0003] Keratoconjunctivitis sicca (also known as dry eye) is one of the most common diseases in ophthalmology clinics. The main symptoms are foreign body sensation, burning sensation and general eye discomfort. These discomforts are typically described as a scraping sensation, dry eyes, pain, grittiness, stinging or burning. [0004] In recent years, supplementing artificia...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61K47/38A61P27/04A61K33/00
Inventor 张艳
Owner SUZHOU BEAUTY OF TAIHU LAKE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products