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Propylene glycol marinate sulfate-containing sustained-release preparation and preparation method thereof

A technology for sustained-release preparations and glycoside esters, which is applied in the directions of medical preparations containing active ingredients, medical preparations with non-active ingredients, and pharmaceutical formulations, etc. Balanced dosing and other issues to achieve the effect of small fluctuation of blood drug concentration, stable release and balanced release

Active Publication Date: 2013-05-15
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing sustained-release preparations of glycosides cannot release glycosides stably within 24 hours, and cannot achieve the effect of sustained release and balanced administration, which needs to be improved

Method used

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  • Propylene glycol marinate sulfate-containing sustained-release preparation and preparation method thereof
  • Propylene glycol marinate sulfate-containing sustained-release preparation and preparation method thereof
  • Propylene glycol marinate sulfate-containing sustained-release preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of embodiment 1 glycoside sugar ester sustained-release preparation

[0021] Take each component by the following parts by weight:

[0022]

[0023] Mix the glycoside sugar ester, the filler and the sustained-release matrix matrix uniformly; add a binder, make a soft material, dry, and granulate; add a lubricant, mix evenly, and compress into tablets to obtain the product.

Embodiment 2

[0024] The preparation of embodiment 2 sugar ester sustained-release preparations

[0025] Take each component by the following parts by weight:

[0026]

[0027] + Mix sugar glycosides, fillers and slow-release matrix matrix methyl cellulose evenly; add binder, make soft material, dry, and granulate; add lubricant, mix evenly, and compress into tablets to obtain the product.

Embodiment 3

[0028] The preparation of embodiment 3 sugar ester sustained-release preparations

[0029] Take each component by the following parts by weight:

[0030]

[0031] Mix glycoside sugar ester, filler and slow-release matrix matrix hydroxypropyl cellulose uniformly; add binder, make soft material, dry and granulate; add lubricant, mix uniformly, and compress into tablets to obtain the product.

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Abstract

The invention discloses a propylene glycol marinate sulfate sustained-release preparation and a preparation method thereof. The propylene glycol marinate sulfate sustained-release preparation comprises: propylene glycol marinate sulfate, a sustained-release skeleton matrix, a filler, a surfactant, a lubricant and a binder. The propylene glycol marinate sulfate sustained-release preparation disclosed in the invention can achieve long-acting release, and can release drug ingredients stably and evenly within 24h.

Description

technical field [0001] The invention relates to a sustained-release preparation, in particular to a glycoside sustained-release preparation and a preparation method thereof, and belongs to the field of glycoside sustained-release preparations. Background technique [0002] Glyceride is the sodium salt of polymannuronic acid propyl ester sulfate obtained by the hydrolysis and esterification of sodium alginate. It is a marine drug for lowering blood fat and antithrombotic, and is used for the treatment of hyperlipidemia. [0003] The sustained-release preparation can stabilize the blood drug concentration after administration, reduce the incidence of adverse reactions, and improve the safety of medication. [0004] The existing sustained-release preparations of glycosides cannot release glycosides stably within 24 hours, and cannot achieve the effect of sustained release and balanced administration, and need to be improved. Contents of the invention [0005] One of the obje...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/715A61K47/38A61K47/32A61K47/34A61K47/36A61P3/06A61K47/26
Inventor 王明刚任莉陈阳生
Owner CP PHARMA QINGDAO CO LTD
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