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Production method of high purity lanolin cholesterol

A technology for lanolin cholesterol and a production method, applied in the field of medicine and chemical industry, can solve the problems of inability to remove impurities of crude lanolin cholesterol, low purity of fine products, long extraction time, etc., and achieve the effects of less impurities, high purity and improved purity

Active Publication Date: 2013-05-15
FUBICHENG SHANGHAI PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The above-mentioned existing crystallization process cannot remove the impurities of crude lanolin cholesterol well, and the extraction time is long, the yield is poor, and the refined product purity of the obtained product is also low, which cannot meet the requirements of high purity (not less than 99% in some fields now). %) market demand for lanolin cholesterol

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1 kg of lanolin (21% cholesteryl ester) and 300ml of 30% sodium hydroxide aqueous solution are thrown in the saponification reaction kettle according to the molar ratio of 1: 1.1, and 900ml of ethanol is added, microwave, power 800W, temperature 78 ℃, microwave reaction for 25 minutes. Add 30% calcium chloride (about 1.2 equivalents) solution of 380ml to the obtained thick slurry, the temperature is 40 DEG C, the power is 800W, microwave reaction is 25 minutes. Ethanol was distilled off by fractional distillation, and the wet weight of the mixture of calcium lanolate and lanolin alcohol was obtained by filtration of 2.4 kg.

Embodiment 2

[0031] To 2.4 kg of calcium lanolate and lanolin alcohol mixture was added 9.6 liters of 95% ethanol. Microwave power 800W, temperature 78°C, time 25 minutes, filter. This operation is repeated once.

Embodiment 3

[0033] Add 0.24g water, take 1,2 propanediol as extraction agent, take cyclohexane as washing agent, the flow ratio of extracting agent, washing agent, raw material liquid three is 2: 0.3: 1, under 20 ℃ in the fractionation extraction device ( There are 10 stages in the extraction section, and 10 stages in the washing section). Fractional distillation extraction is divided into extraction section and washing section. The extraction agent enters the fractionation extraction system from the first stage of the extraction section, and the raw material liquid enters from the last stage of the extraction section. Fractional distillation extraction system, the detergent enters the fractionation extraction system from the first stage of the washing section, and the raw material liquid is combined into the extraction section at the last stage of the extraction section. The extract rich in cholesterol flows out, and the extract is collected, concentrated in vacuo, washed with water and d...

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Abstract

Directed at the defects of the prior art, the invention provides a high efficiency method for extraction and purification of lanolin cholesterol. The method can rapidly extract lanolin cholesterol and maximumly remove impurities, and can enhance the purity of a lanolin cholesterol fine product to over 99%, thus meeting the market demand for high purity lanolin cholesterol. In order to achieve the above purpose, according to a technical scheme involved in the invention, the production method of high-purity lanolin cholesterol is characterized by including the following four steps: saponification, lanolin alcohol extraction, extraction and crystallization, thus obtaining the high purity lanolin cholesterol.

Description

technical field [0001] The invention relates to a method for refining and purifying high-purity lanolin cholesterol, which belongs to the field of medicine and chemical industry. Background technique [0002] Lanolin cholesterol is also called cholesterol, English name: cholesterol, molecular formula: C 22 h 46 O. Cholesterol is mainly used to synthesize VD3; some cosmetics use cholesterol, which has the functions of emulsification, sun protection, and shrinking pores; cholesterol can also be used as molting hormone for shrimp and as an additive for breeding feed. [0003] Lanolin contains about 10-20% cholesterol, which is so high that it cannot be compared with other raw materials. Our country is rich in lanolin resources and low in cost, so extracting cholesterol or cholesterol derivatives from lanolin has great economic value. [0004] CN1594350A discloses a method for extracting lanolin alcohol from the saponification product of lanolin, and adopting the method of s...

Claims

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Application Information

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IPC IPC(8): C07J9/00
Inventor 曹亮
Owner FUBICHENG SHANGHAI PHARMA TECH CO LTD
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