Method and device for dynamically continuously and circularly extracting polygonum multiflorum

A technology of cyclic extraction and Polygonum multiflorum, which is applied in the direction of pharmaceutical formula, solid solvent extraction, plant raw materials, etc., can solve the problems of increasing production cost, consuming large solvent and energy, and low extraction efficiency of active ingredients, so as to reduce energy consumption and Production cost, extraction conditions are mild and controllable

Active Publication Date: 2013-05-22
霸王(广州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The traditional extraction method of Polygonum multiflorum consumes a lot of solvent and energy, and the extraction efficiency of active ingredients is low, which increases the production cost

Method used

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  • Method and device for dynamically continuously and circularly extracting polygonum multiflorum
  • Method and device for dynamically continuously and circularly extracting polygonum multiflorum
  • Method and device for dynamically continuously and circularly extracting polygonum multiflorum

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] A method for extracting Radix Polygoni Multiflori in a dynamic continuous cycle, the steps are as follows:

[0063] Weigh 200g of Polygonum multiflorum powder that has been ultrafinely pulverized for 10 minutes, put it in an extraction tube, add 1000ml of 75% methanol solution, heat it with hot water at 60°C for 40 minutes, adjust the solvent flow rate in the extraction tank to 24ml / min, and release 300ml of the extract in a rotary evaporation Concentrate in the instrument, replenish the solvent in the extraction tube to 1000ml, adjust the flow rate of the solvent in the extraction tube, stop reflux after 3h, and set the volume of the concentrated solution to 500ml at 65°C.

Embodiment 2

[0065] Weigh 200g of Polygonum multiflorum powder that has been ultrafinely pulverized for 5 minutes, put it in an extraction tube, add 850ml of 70% methanol solution, heat it with hot water at 65°C for 45 minutes, adjust the solvent flow rate in the extraction tank to 20ml / min, and release 300ml of the extract solution in a rotary evaporation Concentrate in the instrument, replenish the solvent in the extraction tube to 1000ml, adjust the flow rate of the solvent in the extraction tube, stop the reflux after 3h, and set the volume of the concentrated solution to 500ml at 75°C.

Embodiment 3

[0067] Weigh 200g of Polygonum multiflorum powder that has been ultrafinely pulverized for 15 minutes, put it in an extraction tube, add 1000ml of 80% methanol solution, heat it with hot water at 70°C for 30 minutes, adjust the solvent flow rate in the extraction tank to 30ml / min, and release 300ml of the extract in a rotary evaporation Concentrate in the instrument, replenish the solvent in the extraction tube to 1000ml, adjust the flow rate of the solvent in the extraction tube, stop reflux after 4h, and set the volume of the concentrated solution to 500ml at 80°C.

[0068] In the above embodiment, an online detection port can be set in the extract delivery port and the concentration tank, and the total anthraquinones and stilbene glycosides in Polygonum multiflorum can be detected by far-infrared spectroscopy, ultraviolet-visible spectroscopy, high-performance liquid chromatography or ultra-performance liquid chromatography. content, monitor the change of the content during ...

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Abstract

The invention discloses a method and device for dynamically continuously and circularly extracting polygonum multiflorum. The method comprises the following steps of: drying the polygonum multiflorum, then carrying out superfine grinding, and then adding to an extracting tank; adding a methanol solution with the volume fraction of 70%-80% to the extracting tank; stirring, and extracting through hot water circulation heating for 20-45 minutes; then delivering a polygonum multiflorum crude extracting solution into a low-temperature concentration tank through a liquid medicine pump, and concentrating to needed concentration in vacuum at the temperature of 60-80 DEG C; and delivering a recovered solvent back into the extracting tank through the liquid medicine pump for recycling. The device comprises the extracting tank, a circulating heater, a concentration tank, a vacuum system, a first condenser, a circulating condensing unit, a transit tank and a second condenser, wherein the extracting tank is connected with the circulating heater; the lower part of the extracting tank is connected with the concentration tank through a first liquid medicine pump; the concentration tank is connected with the vacuum system and the first condenser; the first condenser is connected with the circulating condensing unit and the transit tank; the transit tank is connected with the second condenser through a second liquid medicine pump; and the second condenser is connected with the extracting tank. The extraction process and the device disclosed by the invention have the advantages of high extraction rate of total anthraquinone and stibene glucoside which are contained in the polygonum multiflorum, solvent recycling and less consumption.

Description

technical field [0001] The invention relates to a medicinal material extraction method, in particular to a dynamic continuous circulation extraction method and device of Polygonum multiflorum. Background technique [0002] Radix Polygoni Multiflori (Radix Polygoni Multiflori) is the dry root tuber of Polygonum multiflorum Thunb. The traditional Chinese medicine Polygonum Polygoni Multiflori can be divided into Radix Polygoni Multiflori and Radix Polygoni Multiflori Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix L. Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Raw Radix and Radix Radix Radix Radix Radix Radix Radix Radix Raw Radix, and Radix Polygoni Multiflori. Among them, Zhishouwu is mainly used to treat deficiency of essence and blood, dizziness, premature graying of beard and hair, soreness of waist and feet, nocturnal emission, and collapse of the belt. "Compendium of Materia Medica" records: "Invigorating liver and kidney, astrin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61K8/97A61P39/06A61P25/28A61P9/00A61P3/06A61P1/16A61P25/00A61Q19/08B01D11/02
Inventor 陈启源万玉华赖小平李耿张榕文杨广荣
Owner 霸王(广州)有限公司
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