Hydrolyzed collagen liposome for local skin and preparation method thereof

A technology of hydrolyzing collagen and collagen lipids, which is applied in the direction of liposome delivery, peptide/protein components, skin care preparations, etc., can solve the problems of difficulty in improving the encapsulation rate and easy leakage of drugs, and achieve increased stability , Reduce drug leakage, improve the effect of skin retention

Active Publication Date: 2013-05-22
JIANGSU SEMPOLL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are a large number of literature reports on liposome technology, but generally for protein and polypeptide drugs, the molecular weight is relatively large, so it is difficult to improve the encapsulation rate during the encapsulation process, and the drug is also prone to leakage during storage.

Method used

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  • Hydrolyzed collagen liposome for local skin and preparation method thereof
  • Hydrolyzed collagen liposome for local skin and preparation method thereof
  • Hydrolyzed collagen liposome for local skin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1: the preparation of hydrolyzed collagen liposome solution

[0047] The prescription list of table 1 hydrolyzed collagen liposome solution

[0048]

[0049] Preparation process: Dissolve phospholipids, ceramide, and cholesterol in ether, take another hydrolyzed collagen, add water to dissolve, add the ether solution dissolved in phospholipids into the hydrolyzed collagen aqueous solution, and form a stable W / O type emulsion. Then remove the ether under reduced pressure evaporation conditions to obtain a gel-state substance, add dropwise 0.1M pH6.0 phosphate buffer to the above-mentioned substance, vortex and oscillate to make the gel fall off, and continue to evaporate under reduced pressure to obtain the product. Another hyaluronic acid and preservatives are added to the solution for dissolution to obtain a liposome solution.

[0050] The encapsulation efficiency and particle size of the drug were measured, and the results are shown in the table below...

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PUM

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Abstract

The invention provides a hydrolyzed collagen liposome solution mainly used for repairing skin damages caused by various factors. According to the invention, the hydrolyzed collagen liposome solution is prepared from a phospholipid, a ceramide and cholesterol, a percutaneous stratum corneum of hydrolyzed collagen is promoted to enter the skin, and the retention of the hydrolyzed collagen in the skin is improved, so that the recovery of the skin damages is effectively promoted. Furthermore, the solution contains hyaluronic acid to improve the stability of the liposome and delay leakage.

Description

technical field [0001] The invention relates to a local skin hydrolyzed collagen liposome, which is mainly used for promoting the repair of skin damage caused by various reasons. Background technique [0002] Collagen is the main component of the dermis of human skin. It has the function of retaining moisture in the dermis, providing support and protection, and giving the skin elasticity and strength. As we grow older, the collagen in the skin will gradually decrease in metabolism. In addition, ultraviolet rays pass through the epidermis to the dermis, prompting the decomposition of collagen. In the absence of collagen in the skin, the collagen fibers will be solidified, reducing intercellular mucopolysaccharides, and the skin will lose its softness, elasticity and luster. A series of aging phenomena such as spots and wrinkles. The relative molecular mass of collagen is 300,000 Daltons (D). It is a triple helix structure formed by combining 3 peptide chains and intertwined...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61K9/127A61K47/36A61K8/73A61K8/68A61K8/65A61K8/14A61P17/02A61P17/00A61Q19/00
Inventor 付劼王晶
Owner JIANGSU SEMPOLL PHARMA
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