Technology for directly synthesizing acetaminophen from nitrobenzene
A technology of acetaminophen and nitrobenzene, which is applied in the preparation of organic compounds, the preparation of carboxylic acid amides, organic chemistry and other directions, can solve the problems of complex process, large amount of waste liquid in the production process, etc., and achieves high product yield and simplification. Production process, the effect of avoiding the discharge of waste liquid
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Embodiment 1
[0021] In the first step, 0.04 g of zinc sulfate, 0.1 g of Pt / SiO with a Pt loading of 0.1% 2 Catalyst, 2g nitrobenzene, 0.01g hexadecyltrimethylammonium bromide, 0.05g cocatalyst EDTA and 50ml water are put into the autoclave, wherein the zinc ion concentration is 4.9mmol / L;
[0022] In the second step, in the above-mentioned autoclave, with N 2 After replacing the air for 8-12 minutes, heat to 180°C and pass in H 2 , until the hydrogen partial pressure is 1.0MPa, react for 6 hours to convert nitrobenzene into p-aminophenol;
[0023] In the third step, after the reaction of the second step is completed, the reaction solution is filtered while it is hot, and the solid-phase catalyst and the reaction solution are separated;
[0024] In the fourth step, the filtered reaction solution is distilled at 40-100°C under a pressure of 0.05-0.1 MPa to distill off the by-product aniline and part of the water;
[0025] The fifth step is to cool the reaction solution from the aniline se...
Embodiment 2
[0028] In the first step, 0.49 g of zinc nitrate, 0.1 g of Pt / Al with a Pt loading of 0.3% 2 o 3 Catalyst, 2g nitrobenzene, 0.1g cocatalyst EDTA, 0.01g cetyltrimethylammonium bromide and 50ml water are put into autoclave;
[0029] In the second step, in the above-mentioned autoclave, with N 2 After replacing the air for 8 to 12 minutes, heat to 200°C and pass in H 2 , until the partial pressure of hydrogen is 0.1MPa, react for 8 hours to convert nitrobenzene into p-aminophenol;
[0030] In the third step, after the reaction of the second step is completed, the reaction solution is filtered while it is hot, and the solid-phase catalyst and the reaction solution are separated;
[0031] In the fourth step, the filtered reaction solution is distilled at 40-100°C under a pressure of 0.05-0.1 MPa to distill off the by-product aniline and part of the water;
[0032] The fifth step is to cool the reaction solution from the aniline separated in the fourth step to 30-50°C, add the a...
Embodiment 3
[0035] In the first step, 0.01 g of zinc sulfate, 0.3 g of Pt / C catalyst with a Pt loading of 0.01%, 0.1 g of cocatalyst EDTA, 1 g of nitrobenzene, and 0.01 g of hexadecyltrimethyl bromide Ammonium and 50ml water are put into autoclave;
[0036] In the second step, in the above-mentioned autoclave, with N 2 After replacing the air for 8-12 minutes, heat to 80°C and pass in H 2 , until the hydrogen partial pressure is 2.0MPa, react for 5 hours to convert nitrobenzene into p-aminophenol;
[0037] In the third step, after the reaction of the second step is completed, the reaction solution is filtered while it is hot, and the solid-phase catalyst and the reaction solution are separated;
[0038] In the fourth step, the filtered reaction solution is distilled at 40-100°C under a pressure of 0.05-0.1 MPa to distill off the by-product aniline and part of the water;
[0039] The fifth step is to cool the reaction liquid from the aniline separated in the fourth step to 30-50°C, add ...
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