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Application of neurokinin receptor 2 antagonist to treatment of leukemia

A neurokinin, antagonist technology, used to relieve symptoms of cancer in a subject or inhibit the proliferation of cancer cells, a pharmaceutical product, the field of treating cancer in a subject

Inactive Publication Date: 2014-07-16
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first-generation antagonists start with changing tachykinin amino acids, and replace some antagonistic polypeptides with D-amino acids, but their effects are weak, their selectivity is low, and they have neurotoxicity and release histamine.
The second-generation antagonists are short peptide and cyclic peptide antagonists with high affinity and high selectivity obtained on the basis of shortening the peptide chain and chemical modification, but their oral bioavailability is low and metabolism is fast
However, the company has not carried out research on the anti-tumor effect of the organic small molecule, and there is no literature report that it has an anti-tumor effect

Method used

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  • Application of neurokinin receptor 2 antagonist to treatment of leukemia
  • Application of neurokinin receptor 2 antagonist to treatment of leukemia
  • Application of neurokinin receptor 2 antagonist to treatment of leukemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0040] 1. Materials and Methods

[0041] 1.1 Materials, instruments and reagents

[0042] 1.1.1 Cell lines

[0043] Human chronic myeloid leukemia cells K562 and mouse erythroleukemia MEL cells were purchased from the Chinese Academy of Medical Sciences Tumor Cell Bank. Neurokinin receptor 1 antagonist SR140333 and neurokinin receptor 2 antagonist SR48968 were provided by Sanofi-Synthelabo, France.

[0044] 1.1.2 Main reagents

[0045] DMEM medium Gibco company

[0046] FBS Hyclone

[0047] DMSO Sigma-Aldrich

[0048] 1.1.3 Reagent preparation

[0049] Phosphate buffer saline (PBS): 8g sodium chloride, 0.2g potassium chloride, 2.9g disodium hydrogen phosphate, 0.2g potassium dihydrogen phosphate, 1L deionized water, store at 4°C.

[0050] SR140333 and SR48968 were dissolved in DMSO respectively, and then added in PBS to make 9×10 -3 Mother liquor of M. The concentration of DMSO in the working solution is less than 1%. The prepared mother liquor was sterilized by filt...

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Abstract

The present invention relates to the anticancer effect of neurokinin receptor antagonists, in particular to: a method for treating cancer in a subject, relieving cancer symptoms in a subject, or inhibiting the proliferation of cancer cells; the neurokinin receptor antagonist is prepared Use in a drug, medicament or pharmaceutical composition for treating cancer, relieving cancer symptoms or inhibiting cancer cell proliferation; and a pharmaceutical product comprising an antagonist of a neurokinin receptor as an active ingredient and comprising the pharmaceutical Product manual.

Description

[0001] This application is a divisional application of Chinese Patent Application No. 2011100704701 entitled "Anticancer Effect of Neurokinin Receptor Antagonist". technical field [0002] The present invention relates to the anticancer effects of neurokinin receptor antagonists. Specifically, the present invention relates to: methods for treating cancer in a subject, relieving cancer symptoms in a subject, or inhibiting the proliferation of cancer cells; antagonists of neurokinin receptors are used in the preparation of treatments for cancer, alleviating cancer symptoms, or inhibiting cancer Use in a drug, medicament or pharmaceutical composition for cell proliferation; and a pharmaceutical product comprising an antagonist of a neurokinin receptor as an active ingredient and instructions relating to the pharmaceutical product. Background technique [0003] Cancer is a kind of disease that seriously endangers human health. At present, the global cancer death toll is highe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/451A61P35/00
Inventor 付彩云夏瑞龙赵辅昆张世馥陈攀峰王宇沙
Owner ZHEJIANG SCI-TECH UNIV
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