Drug-loaded stent with ultrasonic intelligent controlled release
A technology of intelligent controlled release and ultrasound, applied in the field of stents, to achieve the effect of reducing toxic side effects and high clinical application value
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Embodiment 1
[0042] Example 1 Synthesis of amphiphilic block copolymer P-(NIPAAm-co-NHMAAm) and drug-loaded stent material
[0043] 1. Synthesis of amphiphilic block copolymers:
[0044] 1. Synthesis of Raft chain transfer agent S-1-dodecyl-S'-(α,α'-dimethyl-α''-acetic acid) trithioester (DMP)
[0045]
[0046] A mixture of 0.25 g tetramethylammonium bromide (1.6 mmol), 8.1 g dodecanethiol (0.04 mol) and 19.24 g acetone (0.33 mol) was stirred and cooled to 0°C, and 3.35 g of 50 wt% NaOH solution. After 20 min, a mixture consisting of 3.04 g of carbon disulfide (0.04 mol) and 5.2 mL of acetone was added dropwise within 20 min. When the reaction system starts to turn red, slowly add 7.13g CHCl 3 (0.06mol), and then 16 g of 50 wt% NaOH solution was added dropwise within 15 min. The system was stirred overnight at 0°C. After the reaction, add 60mL H to the system 2 O, then add concentrated hydrochloric acid to acidify. After stirring to remove acetone, the crude product was dissolve...
Embodiment 2
[0060] Example 2 Characterization of polymers and polymer nanoparticles
[0061] Polymer Structural Characterization:
[0062] P-(NIPAAM-b-HMAAM) copolymer structure uses Fourier transform infrared spectrometer (FTIR) (Bruker, Equinoxss / Hyperion2000), nuclear magnetic resonance spectrometer (NMR) (Bruker, Anance400), polymer powder is directly used in FTIR test ATR method test; NMR test with CDCl 3 As a solvent; use GPC (waters) to determine the molecular weight and molecular weight distribution index.
[0063] Polymer temperature-sensitive property test:
[0064] The LCST of the copolymer aqueous solution was determined by turbidimetry; 5 mg of P-(NIPAAM-b-HMAAM) copolymer was dissolved in 10 mL of deionized water to obtain the aqueous solution of P-(NIPAAM-b-HMAAM). The light transmittance of the polymer aqueous solution was measured at a wavelength of 450 nm by ultraviolet spectroscopy (U-3310, Hitachi). The sample cell was kept at constant temperature with a temperatur...
Embodiment 3
[0090] Example 3 Field emission scanning electron microscopy and acoustic microscopy detection of surface changes before and after drug release in each material group
[0091] 1. Experimental equipment:
[0092] Field Emission Scanning Electron Microscope: Specification Model: Quanta 200 FEG Manufacturer: FEI Company, USA.
[0093] Electron Acoustic Microscope Imaging System (Kristide, HIROX-7700): It is used to detect the heat wave generated by the substance after absorbing light energy and the acoustic signal generated after the substance is excited. It can be used to observe the conformational changes on the surface of the material. Advantages of non-destructive and dynamic analysis.
[0094] 2. Experimental analysis results:
[0095] Please refer to the attached Figure 7 , with Figure 7 It is electron acoustic microscope scanning picture before and after drug release of each group of materials. The graphs are all the scanning results under the condition of ×400 magn...
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