Drug-loaded stent with ultrasonic intelligent controlled release

A technology of intelligent controlled release and ultrasound, applied in the field of stents, to achieve the effect of reducing toxic side effects and high clinical application value

Inactive Publication Date: 2012-01-18
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report about a temperature-sensitive coated drug-coated drug-loaded stent with ultrasonic controlled release and its preparation method and application.

Method used

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  • Drug-loaded stent with ultrasonic intelligent controlled release
  • Drug-loaded stent with ultrasonic intelligent controlled release
  • Drug-loaded stent with ultrasonic intelligent controlled release

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 Synthesis of amphiphilic block copolymer P-(NIPAAm-co-NHMAAm) and drug-loaded stent material

[0043] 1. Synthesis of amphiphilic block copolymers:

[0044] 1. Synthesis of Raft chain transfer agent S-1-dodecyl-S'-(α,α'-dimethyl-α''-acetic acid) trithioester (DMP)

[0045]

[0046] A mixture of 0.25 g tetramethylammonium bromide (1.6 mmol), 8.1 g dodecanethiol (0.04 mol) and 19.24 g acetone (0.33 mol) was stirred and cooled to 0°C, and 3.35 g of 50 wt% NaOH solution. After 20 min, a mixture consisting of 3.04 g of carbon disulfide (0.04 mol) and 5.2 mL of acetone was added dropwise within 20 min. When the reaction system starts to turn red, slowly add 7.13g CHCl 3 (0.06mol), and then 16 g of 50 wt% NaOH solution was added dropwise within 15 min. The system was stirred overnight at 0°C. After the reaction, add 60mL H to the system 2 O, then add concentrated hydrochloric acid to acidify. After stirring to remove acetone, the crude product was dissolve...

Embodiment 2

[0060] Example 2 Characterization of polymers and polymer nanoparticles

[0061] Polymer Structural Characterization:

[0062] P-(NIPAAM-b-HMAAM) copolymer structure uses Fourier transform infrared spectrometer (FTIR) (Bruker, Equinoxss / Hyperion2000), nuclear magnetic resonance spectrometer (NMR) (Bruker, Anance400), polymer powder is directly used in FTIR test ATR method test; NMR test with CDCl 3 As a solvent; use GPC (waters) to determine the molecular weight and molecular weight distribution index.

[0063] Polymer temperature-sensitive property test:

[0064] The LCST of the copolymer aqueous solution was determined by turbidimetry; 5 mg of P-(NIPAAM-b-HMAAM) copolymer was dissolved in 10 mL of deionized water to obtain the aqueous solution of P-(NIPAAM-b-HMAAM). The light transmittance of the polymer aqueous solution was measured at a wavelength of 450 nm by ultraviolet spectroscopy (U-3310, Hitachi). The sample cell was kept at constant temperature with a temperatur...

Embodiment 3

[0090] Example 3 Field emission scanning electron microscopy and acoustic microscopy detection of surface changes before and after drug release in each material group

[0091] 1. Experimental equipment:

[0092] Field Emission Scanning Electron Microscope: Specification Model: Quanta 200 FEG Manufacturer: FEI Company, USA.

[0093] Electron Acoustic Microscope Imaging System (Kristide, HIROX-7700): It is used to detect the heat wave generated by the substance after absorbing light energy and the acoustic signal generated after the substance is excited. It can be used to observe the conformational changes on the surface of the material. Advantages of non-destructive and dynamic analysis.

[0094] 2. Experimental analysis results:

[0095] Please refer to the attached Figure 7 , with Figure 7 It is electron acoustic microscope scanning picture before and after drug release of each group of materials. The graphs are all the scanning results under the condition of ×400 magn...

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Abstract

The invention relates to a stent coating with ultrasonic intelligent controlled release and a preparation method and an application thereof. The invention also provides a drug-loaded stent with ultrasonic intelligent controlled release and a preparation method and an application thereof. The advantages of the invention are that: a new stent coating with the effect of ultrasonic intelligent controlled release is successfully constructed and synthesized; ultrasound is first found and confirmed to have control effect on the temperature-sensitive release of loaded drugs; and a new method is provided for future drug intelligent controlled release; a drug-loaded biliary tract stent with ultrasonic intelligent drug controlled release is synthesized, and a possible and feasible treatment means is provided for the treatment of malignant tumors of hollow organs; ultrasound is first found and confirmed to have significant effect on promoting the release of drugs coated by a temperature-sensitive material by changing the spatial structure of the temperature-sensitive material. By using ultrasound, the effect of drug intelligent controlled release at a designated site is achieved; local anticancer effect is brought into play; the toxic and side effect of anticancer drugs on important human tissue is reduced; and high clinical application value is provided.

Description

technical field [0001] The invention relates to a stent, in particular to a drug-loaded stent with a temperature-sensitive coated drug coating and an ultrasonic intelligent controlled release, as well as a preparation method and application thereof. Background technique [0002] In the field of interventional therapy, for the stenosis of blood vessels, trachea, esophagus, urethra, biliary tract and other organs, stents are usually implanted to expand the stenosis and effectively maintain the lumen. The stent is introduced into the lumen in the unexpanded state, positioned at the stenosis, expanded and placed there. Then people invented the drug-eluting stent on the basis of the stent. The drug-eluting stent is also called a drug-releasing stent, and the drug is carried by the polymer coated on the surface of the metal stent. Drug release from the polymer coating by elution. Most of the current drug-eluting stents are directly coated with hydrophobic polymers such as polyla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/14A61L31/16
Inventor 李松岗全志伟谭庆刚王雪峰李济宇
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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