An automatic cell culture device capable of simulating internal environments of organisms

A cell culture and culture device technology, applied in the field of cell culture, can solve problems such as lack of design and difficulty in meeting specific cell culture requirements, and achieve the effect of increasing the contact area and time, improving the quality of cell culture, and improving the quality of culture

Active Publication Date: 2013-06-19
GUANGZHOU YIDAI PHARMA
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

The growth and differentiation of cells depends on the specific growth environment of the body and the interaction between cells, such as the hypoxic and hypotonic environment of embryonic stem cells, the internal testis environment during the development and maturation of germ cells, the thymus environment that induces

Method used

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  • An automatic cell culture device capable of simulating internal environments of organisms
  • An automatic cell culture device capable of simulating internal environments of organisms

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Embodiment 2

[0030] Such as figure 2 As shown, this embodiment is basically the same as Embodiment 1, the difference is that there are two internal environment simulation devices, including a first internal environment simulation tissue and organ culture device 2a for simulating the internal environment of thymus and lymph nodes and The internal environment simulating tissue and organ culture device 2b for simulating the internal environment of the tumor can correspondingly transport the effector cells obtained from the medical cell induction culture device 1 to the first internal environment simulating tissue and organ culture device 2a or the second internal environment In the simulated tissue and organ culture device 2b, the internal environment of the body is simulated through the cooperation of the pressure difference between the positive pressure liquid exchange tube 42 and the negative pressure liquid exchange tube 44, and the liquid exchange capillary network 43 prolongs the effect...

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Abstract

The invention belongs to the technical field of cell culture, particularly discloses an automatic cell culture device capable of simulating internal environments of organisms. The automatic cell culture device comprises a laminar flow sterile sealed chamber. An internal environment simulation tissue and organ culture device and a target cell induction culture device are arranged in the sealed chamber. The automatic cell culture device can simulate the internal environments including a low-oxygen low-permeability environment for culturing embryonic stem cells, a testicular internal environment during maturation of germ cells, a thymus environment for inducing maturation of T cells, a cerebrospinal fluid environment for inducing differentiation of neural stem cells and tissue and organ environments such as livers, pancreas, bone marrow and tumors for inducing differentiation and maturation of corresponding stem cells, and cultures specific high-quality cells in an induction mode to meet needs of cell basic researches and applications. Besides, the simulated internal environments provide a basis for researching an organism cell growth, differentiation and maturation mechanisms. Therefore, the improvement of cell culture quality is facilitated, repeatability of cytology researches is remarkably increased, cost of cell culture is saved, clinic transformation and application of the cell culture technology are quickened, and a good experiment platform is provided for scientific research basic workers.

Description

technical field [0001] The invention belongs to the technical field of cell culture. Specifically disclosed is an automatic cell culture device for simulating the internal environment of a body. Background technique [0002] Cell culture is the basis of bioengineering, biopharmaceuticals, sustainable utilization of biological resources and cell medicine. A sound cell culture technology system is the key to scientific research, production and medical applications. Cells in the body live in different environments during the process of growth and differentiation, and their biological characteristics will also change with the environment. To cultivate cells that truly reflect the characteristics of the body in vitro, a suitable biological environment is required. For example, the hypoxic and hypotonic environment of embryonic stem cells, the testicular environment during germ cell development and maturation, the thymus environment for inducing T cell maturation, the bone marro...

Claims

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Application Information

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IPC IPC(8): C12M3/00C12M1/38C12M1/36
Inventor 汪华张雁
Owner GUANGZHOU YIDAI PHARMA
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