High-pressure extruding and filtering system for preparing liposome

A filtration system and high-pressure technology, which is applied in the direction of making medicines into special physical or taking forms of devices, etc., can solve the problem of liposome-susceptible bacteria, inability to meet the requirements of liposome pharmaceutical production, and troublesome use, operation and maintenance. and other problems, to achieve precise control of particle size, improve efficiency, and avoid the effects of contamination.

Active Publication Date: 2013-07-10
安拓思纳米技术(苏州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing equipment is a separate high-pressure homogenizer and a low-pressure (1-10bar) filter. Liposomes are prone to bacterial contamination when replacing the filter membrane, which cannot meet the requirements for liposome pharmaceutical production, and it is troublesome to operate and maintain

Method used

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  • High-pressure extruding and filtering system for preparing liposome
  • High-pressure extruding and filtering system for preparing liposome
  • High-pressure extruding and filtering system for preparing liposome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 , Liposome preparation high pressure extrusion filtration system

[0024] Such as Figure 1 to Figure 6 A kind of liposome shown prepares high-pressure extrusion filtration system, comprises high-pressure homogenizer 21 and four high-pressure extruders 20 that are placed side by side, and described high-pressure extruder 20 comprises feed pipe 1, flange fixing bolt 2. The inner gasket of the feeding flange 3, the constant temperature water outlet 4, the support foot 5, the discharge pipe 6, the bottom plate of the constant temperature tank 7, the outer gasket 8 of the bottom plate, the constant temperature water inlet 9, and the base 10, Extrusion outer gasket 11, support plate 12, filter plate 13, filter membrane 14, extrusion inner gasket 15, feed flange 16, upper cover 17, locking bolt 18 and handle 19, the support foot 5 Connected with the base 10 through threads; the bottom plate 7 of the constant temperature bath is connected with the base 10 through ...

Embodiment 2

[0025] Example 2 , Liposome preparation high pressure extrusion filtration system

[0026] Such as Figure 1 to Figure 6Shown a kind of liposome prepares high-pressure extrusion filtration system, comprises high-pressure homogenizer 21 and two high-pressure extruders 20 that are placed side by side, and described high-pressure extruder 20 comprises feed pipe 1, flange fixing bolt 2. The inner gasket of the feeding flange 3, the constant temperature water outlet 4, the support foot 5, the discharge pipe 6, the bottom plate of the constant temperature tank 7, the outer gasket 8 of the bottom plate, the constant temperature water inlet 9, and the base 10, Extrusion outer gasket 11, support plate 12, filter plate 13, filter membrane 14, extrusion inner gasket 15, feed flange 16, upper cover 17, locking bolt 18 and handle 19, the support foot 5 Connected with the base 10 through threads; the bottom plate 7 of the constant temperature bath is connected with the base 10 through th...

Embodiment 3

[0027] Example 3 , Liposome preparation high pressure extrusion filtration system

[0028] Such as Figure 1 to Figure 6 A kind of liposome shown prepares high-pressure extrusion filtration system, comprises high-pressure homogenizer 21 and four high-pressure extruders 20 that are placed side by side, and described high-pressure extruder 20 comprises feed pipe 1, flange fixing bolt 2. The inner gasket of the feeding flange 3, the constant temperature water outlet 4, the support foot 5, the discharge pipe 6, the bottom plate of the constant temperature tank 7, the outer gasket 8 of the bottom plate, the constant temperature water inlet 9, and the base 10, Extrusion outer gasket 11, support plate 12, filter plate 13, filter membrane 14, extrusion inner gasket 15, feed flange 16, upper cover 17, locking bolt 18 and handle 19, the support foot 5 Connected with the base 10 through threads; the bottom plate 7 of the constant temperature bath is connected with the base 10 through ...

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Abstract

The invention discloses a high-pressure extruding and filtering system for preparing liposome. The high-pressure extruding and filtering system disclosed by the invention comprises a high-pressure homogenizer and one or a plurality of high-pressure extruders in parallel arrangement, wherein the high-pressure extruder comprises a feeding pipe, a flange fixing bolt, a feeding flange inner sealing gasket, a constant-temperature water discharging opening, a discharging pipe, a constant-temperature tank base plate, a base plate outer sealing gasket, a constant-temperature water feeding opening, a base, an extrusion outer sealing gasket, a supporting plate, a filtering plate, a filtering film, an extrusion inner sealing gasket, a feeding flange, an upper cover and a locking bolt; the feeding pipe is arranged at the upper part of the high-pressure extruder and connected to the discharging opening of the high-pressure homogenizer; and a valve is arranged at the opening of the feeding pipe. The high-pressure extruding and filtering system disclosed by the invention is connected with one or plurality of high-pressure extruders and the high-pressure extruders are freely switched via the valve, so that the liposome is prevented from being inflected by bacterium in the process of replacing the filtering film, the extrusion efficiency is improved, the liposome with large particle diameter is effectively reduced, the precise control of the particle diameter can be realized and the requirement of preparation of liposome medicament can be satisfied.

Description

technical field [0001] The invention relates to a processing equipment for preparing liposomes, in particular to a high-pressure extrusion filtration system for preparing liposomes. Background technique [0002] When amphiphilic molecules such as phospholipids and sphingolipids are dispersed in the aqueous phase, the hydrophobic tails of the molecules tend to gather together and avoid the aqueous phase, while the hydrophilic heads are exposed to the aqueous phase, forming closed vesicles with a bilayer structure , called liposomes, ranging from 25 to 1000 nm in diameter. Liposome is a targeted drug carrier, which belongs to a new dosage form of targeted drug delivery system. It can embed drug powder or solution in nanometer-sized particles, which have a cell-like structure, enter the human body and be swallowed by the reticuloendothelial system to activate the body's autoimmune function and change the encapsulated drug The distribution in the body makes the drug mainly acc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C47/68A61J3/00B29C48/693B29C48/03
CPCB29C48/03B29C48/693
Inventor 童舸嵇洪将
Owner 安拓思纳米技术(苏州)有限公司
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