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Compound paracetamol glucose zinc tablet and preparation method thereof

A technology of compound aminophenol glucosamine and zinc gluconate, applied in the field of medicine, can solve the problems of large content of excipients, affecting tablet performance, etc., and achieve the effect of improving product quality

Active Publication Date: 2015-08-26
HEBEI HENGLI GRP PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if the content of excipients is too large, it may affect the performance of other aspects of the tablet

Method used

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  • Compound paracetamol glucose zinc tablet and preparation method thereof
  • Compound paracetamol glucose zinc tablet and preparation method thereof
  • Compound paracetamol glucose zinc tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Preparation of Example 1 Compound Paracetamol Glucose Tablets

[0021] The formula is as follows:

[0022]

[0023]

[0024] 1) Preparation of compound paracetamol and glucose zinc tablet core: mix paracetamol, zinc gluconate, Radix Radix Radix Extract powder, dioxpromazine hydrochloride, starch, pulverize, with 2% by weight of hypromellose aqueous solution Granulating the binder, then adding sodium carboxymethyl starch and magnesium stearate, mixing evenly, and compressing into tablets, so as to obtain the compound zinc glutamate tablet core; and

[0025] 2) Add the film coating premix into water and stir to prepare a coating liquid, then put the compound paracetamol zinc glucose tablet core into a coating pan and heat it to 40°C, and spray the Coating solution, after spraying, just let it dry.

Embodiment 2

[0026] Preparation of Example 2 Compound Paracetamol Glucose Tablets

[0027] The same method as in Example 1 was used to prepare compound zinc glutamate tablets, except that 1 gram of sodium starch glycolate and 5 grams of hypromellose were used per thousand tablets.

Embodiment 3

[0028] Embodiment 3 Preparation of Compound Paracetamol Glucose Tablets

[0029] The compound zinc glutamate tablets were prepared in the same manner as in Example 1, except that 30 grams of sodium starch glycolate and 1 gram of hypromellose were used per thousand tablets.

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Abstract

The invention relates to a compound prcetmol zinc gluconte tablet, which is prepared from acetaminophen, zinc gluconate, dioxopromethazine hydrochloride, isatis-root extract powder and an auxiliary material, wherein the auxiliary material comprises sodium carboxymethyl starch and hydroxypropyl methylcellulose; and each compound prcetmol zinc gluconte tablet contains 1-30mg of sodium carboxymethyl starch and 1-5mg of hydroxypropyl methylcellulose. The invention also relates to a preparation method of the compound prcetmol zinc gluconte tablet. The compound prcetmol zinc gluconte tablet product disclosed by the invention is an over-the-counter drug for subcalorism, and is used for symptomatic treatment of nasal obstruction, running nose, fever, headache, cough, profuse phlegm and the like caused by common cold or epidemic bronchitis. By adopting the compound prcetmol zinc gluconte tablet disclosed by the invention, the dissolution rate of acetaminophen is improved, the tablet friability is improved, and the product quality is further improved.

Description

technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to compound aminophenol glucose zinc tablet and a preparation method thereof. Background technique [0002] Compound Paracetamol Glucose Zinc Tablets is an over-the-counter medicine for colds developed and produced by Hebei Hengli Group Pharmaceutical Co., Ltd. Currently commercially available Compound Aminophen Glucose Zinc Tablets are film-coated tablets, each tablet contains 100mg of paracetamol, 70mg of zinc gluconate, 1mg of dioxpromazine hydrochloride, 250mg of Radix Radix Radix Extract powder, and the excipients are starch, magnesium stearate, Film coating premix. [0003] During the research process, it was found that zinc gluconate, dioxpromazine hydrochloride, and Radix Radix Radix extract powder in Compound Paracetamol Glucose Tablets are easily soluble in water, and a large dose of acetaminophen is slightly soluble in water, and is monoclinic , Weak bindi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/38A61K47/36A61K9/28A61K36/195A61K36/315A61P11/00A61P31/16A61K31/167A61K31/315A61K31/5415
Inventor 赵西茹宋志刚张建文吴国强吴明军
Owner HEBEI HENGLI GRP PHARM CO LTD
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