Synthesis method of fenpropimorph

Abstract

The invention discloses a synthesis method of fenpropimorph. The method adopts p-tert-butyl-beta-methylphenylpropanol as a start raw material and comprises the following steps of: performing esterification by use of methylsufonyl chloride or performing chlorination by use of thionyl chloride to synthesize an intermediate; and synthesizing by use of the intermediate and 2,6-dimethylmorpholine to generate fenpropimorph. The method disclosed by the invention has the advantages of high reaction yield, no environmental pollution, high finished product content, simple process, industrial production value, easiness in operation, simple equipment, few three wastes, low cost and the like.

Description

technical field

[0001] The invention relates to a method for synthesizing fenpropimorph. Background technique

[0002] Fenpropimorph (Fenpropimorph), also known as Fenpropimorph, Prophyllin, the chemical name is (±) cis 4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6 -Dimethylmorpholine, the pure product is a colorless, oily liquid with an aromatic odor, with a boiling point of 392°C (101.3kPa), and is a systemic morpholine fungicide with preventive and therapeutic effects and ergosterol reduction Inhibitors.

[0003] The chemical structural formula is:

[0004]

[0005] The existing domestic synthesis process of fenpropimorph is shown in the figure below: 2-methyl-4-p-tert-butyl benzaldehyde is obtained by condensation with propionaldehyde under alkaline conditions using p-tert-butylbenzaldehyde as the starting material Phenylacrolein, and then undergo selective hydrogenation reduction to obtain 2-methyl-4-p-tert-butylphenylpropanal, and finally react with 2,6-dimethylm...

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