Application of two new triterpene lactones compounds in rehmannia glutinosa leaves in preparation of anti-tumour drug
A technology for rehmannia triterpenoid lactones and ester compounds, applied in the field of medicine, can solve problems such as no public reports, and achieve the effects of low cost, convenient operation and simple method
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Embodiment 1
[0047] Take 3 kg of yellow leaves from Wenxian County, Henan Province, crush them, and use a flash extractor to crush and extract three times in acetone aqueous solution with a volume concentration of 50% at room temperature at 25°C. The amount of acetone aqueous solution added each time is 25L, and each time is 15-20 minutes. Combined extraction solution, the solvent was recovered under reduced pressure at 45°C, and 1235 g of dry powder was obtained after vacuum drying. The dry powder was dispersed and dissolved in water, centrifuged, and the supernatant was applied to a macroporous adsorption resin column Diaion HP-20, washed with water until the eluent was colorless, and then washed with volume Wash with methanol with a concentration of 10% until the eluent is colorless, wash with methanol with a volume concentration of 20% until the eluent is colorless, wash with methanol with a volume concentration of 30% until the eluent is colorless, and finally use a volume concentration...
Embodiment 2
[0055] Take 6 kg of yellow leaves from Wuzhi, Henan, grind them, and extract them three times with a flash extractor at a room temperature of 25°C. Each time, 50 L of acetone aqueous solution with a volume concentration of 50% is added to the ground yellow leaves powder for solvent extraction, each time for 15-20 minutes, and combined Three extractions, the solvent was recovered under reduced pressure at 45°C, and 2510 g of dry powder was obtained after vacuum drying. The dry powder was dispersed and dissolved in water, and centrifuged to obtain a supernatant, which was applied to a macroporous adsorption resin column Diaion HP-20, washed with water until eluted The liquid is colorless, and then washed with methanol with a volume concentration of 10% until the eluent is colorless, washed with methanol with a volume concentration of 20% until the eluent is colorless, and washed with methanol with a volume concentration of 30% until the elution The liquid is colorless, and finall...
Embodiment 3
[0063] Take 9 kg of yellow leaves from Mengxian County, Henan Province and grind them, extract them three times with a flash extractor at a room temperature of 25°C, add 75 L of acetone aqueous solution with a volume concentration of 50% to each time for solvent extraction, each time for 15-20 minutes, and combine Three extractions, the solvent was recovered under reduced pressure at 45°C, and 3710 g of dry powder was obtained after vacuum drying. The dry powder was dispersed and dissolved in water, and centrifuged to obtain a supernatant. The supernatant was applied to a macroporous adsorption resin column Diaion HP-20, washed with water until elution The liquid is colorless, and then washed with methanol with a volume concentration of 10% until the eluent is colorless, washed with methanol with a volume concentration of 20% until the eluent is colorless, and washed with methanol with a volume concentration of 30% until the elution The liquid is colorless, and finally washed w...
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