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Children calcium gluconate-milk composition freeze-dried oral disintegrating tablet and preparation method thereof

A technology of calcium gluconate and orally disintegrating tablets, applied in the field of freeze-dried orally disintegrating tablets of calcium gluconate milk composition for children and its preparation, can solve the problems of high tablet hardness, unsuitability for children, and sandy feeling, etc. achieve full absorption

Inactive Publication Date: 2013-09-11
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, oral preparations often need to be taken with water or the tablets are very hard, which will be difficult for patients with difficulty swallowing or inconvenient water intake, especially for children. It is very inconvenient to take. The calcium gluconate orally disintegrating tablets sold on the market are Using a variety of excipients and disintegrating agents, it is made by pressing with a traditional tablet machine. It takes at least 30 seconds to disintegrate in the human oral cavity, and it feels sandy in the mouth, which is not suitable for children. In view of this, it is proposed this invention

Method used

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  • Children calcium gluconate-milk composition freeze-dried oral disintegrating tablet and preparation method thereof
  • Children calcium gluconate-milk composition freeze-dried oral disintegrating tablet and preparation method thereof
  • Children calcium gluconate-milk composition freeze-dried oral disintegrating tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Prescription: 1000 tablets

[0032]

[0033]

[0034] Dissolve the prescribed amount of milk powder, mannitol, and sucralose in purified water of 70%-80% of the total prescription water, heat to 40°C while stirring, slowly add the prescribed amount of calcium gluconate, and add the prescribed amount Dissolve a certain amount of gelatin in purified water with 20% of the prescribed water consumption, heat to dissolve completely, combine the above two solutions and stir evenly, according to the specifications of the calcium gluconate milk composition freeze-dried orally disintegrating tablets for children, after determining the loading, put The combined medicinal liquid is divided into containers according to the loading amount, and put into a freeze-drying box to freeze the medicinal liquid. Seal it and pack it after taking it out.

Embodiment 2

[0036] Prescription: 1000 tablets

[0037]

[0038] Dissolve the prescribed amount of milk powder, mannitol, and sucralose in purified water of 70%-80% of the total prescription water, heat to 40°C while stirring, slowly add the prescribed amount of calcium gluconate, and add the prescribed amount Dissolve a certain amount of gelatin in purified water with 20% of the prescribed water consumption, heat to dissolve completely, combine the above two solutions and stir evenly, according to the specifications of the calcium gluconate milk composition freeze-dried orally disintegrating tablets for children, after determining the loading, put The combined medicinal liquid is divided into containers according to the loading amount, and put into a freeze-drying box to freeze the medicinal liquid. Seal it and pack it after taking it out.

Embodiment 3

[0040] Prescription: 1000 tablets

[0041]

[0042] Dissolve the prescribed amount of milk powder, mannitol, and sucralose in purified water of 70%-80% of the total prescription water, heat to 40°C while stirring, slowly add the prescribed amount of calcium gluconate, and add the prescribed amount Dissolve a certain amount of gelatin in purified water with 20% of the prescribed water consumption, heat to dissolve completely, combine the above two solutions and stir evenly, according to the specifications of the calcium gluconate milk composition freeze-dried orally disintegrating tablets for children, after determining the loading, put The combined medicinal liquid is divided into containers according to the loading amount, and put into a freeze-drying box to freeze the medicinal liquid. Seal it and pack it after taking it out.

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PUM

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Abstract

The invention provides a children calcium gluconate-milk composition. The composition comprises the following ingredients in percentage by weight: 0.2-0.8% of calcium gluconate, 1.3-2.4% of mannitol, 2-4% of gelatin, 90-97% of milk powder, and 0.1-0.15% of sucralose. The invention also provides a children calcium gluconate-milk composition freeze-dried oral disintegrating tablet which is prepared from the composition. The freeze-dried oral disintegrating tablet is simple in ingredients, less in intestinal residue, complete in absorption, good in taste, and especially suitable for an infant to take, and does not need water and chewing when taken, and the disintegrating time of the freeze-dried oral disintegrating table in an oral cavity of a human body is not more than 2 seconds.

Description

technical field [0001] The invention relates to a calcium gluconate milk composition for children, and more specifically, to a freeze-dried orally disintegrating tablet of the calcium gluconate milk composition for children and a preparation method thereof. Background technique [0002] Calcium is the most abundant inorganic substance in the body, and it is necessary to maintain the normal function of human nerves, muscles, skeletal system, cell membrane and capillary permeability. Calcium ions are important activators of many enzymatic reactions and are necessary for many physiological processes, such as nerve impulse transmission, contraction of smooth and skeletal muscles, renal function, respiration and blood coagulation, etc. [0003] Calcium gluconate is white crystalline or granular powder. The melting point is 201°C (decomposition). Soluble in water (3g / 100ml, 20℃), easily soluble in boiling water (20g / 100ml), the pH of the aqueous solution is about 6-7. Insoluble...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/191A23L1/29A61P3/02A61P37/08A23L33/00
Inventor 汪峰汪金灿
Owner HAINAN WEI KANG PHARMA QIANSHAN