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Traditional Chinese medicinal composition for treating intestinal mucosa damage and preparation method and application thereof

A technology of intestinal mucosal injury and composition, applied in the field of traditional Chinese medicine, to achieve the effect of reducing clinical symptoms, strengthening repairing effect, and reducing intestinal mucosal injury

Inactive Publication Date: 2015-07-22
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no medicine for the treatment of intestinal mucosal damage after colorectal cancer surgery and / or chemotherapy that is made the same as the composition of the present invention.

Method used

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  • Traditional Chinese medicinal composition for treating intestinal mucosa damage and preparation method and application thereof
  • Traditional Chinese medicinal composition for treating intestinal mucosa damage and preparation method and application thereof
  • Traditional Chinese medicinal composition for treating intestinal mucosa damage and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Granules

[0032] Weigh the raw materials: Dangshen 100g, Atractylodes 200g, Poria 100g, Pueraria lobata root 200g, Scutellaria 50g, Coptis 150g, Astragalus 100g.

[0033] Add 8 times the amount of water to the above-mentioned API, extract once by heating and refluxing for 2 hours each time, filter, combine the extracts, concentrate and dry to obtain 180g of dry extract, pulverize into fine powder, add conventional formulation excipients, and mix well Granulate and package into 100 packets of granules. Each contains 1800mg of traditional Chinese medicine composition. Usage: 1 sachet each time, 3 times a day, 7 days a week, 4 weeks as a course of treatment.

Embodiment 2

[0034] Example 2 Tablet

[0035] Weigh the raw materials: Codonopsis 200g, Baizhu 100g, Poria 200g, Pueraria lobata root 100g, Scutellaria 150g, Coptis 30g, Astragalus 200g.

[0036] Add 15 times the amount of water to the above-mentioned API, extract 2 times at reflux for 1 hour each time, filter, combine the extracts, concentrate and dry to obtain 182g of dry extract, crush it into fine powder, add conventional formulation excipients, and mix well Granulation, compressed into tablets, tablet weight 600mg. Each tablet contains 440mg of traditional Chinese medicine composition. Usage: 4 tablets each time, 3 times a day, 7 days a week, 4 weeks as a course of treatment.

Embodiment 3

[0037] Example 3 Capsules

[0038] Weigh the raw materials: Codonopsis 160g, Baizhu 160g, Poria 160g, Pueraria lobata root 160g, Scutellaria baicalensis 80g, Coptis 80g, Astragalus 160g.

[0039] Add 10 times the amount of water to the above-mentioned API, extract 2 times by heating and refluxing for 1 hour each time, filter, combine the extracts, concentrate and dry to obtain 185g of dry extract, pulverize into fine powder, add conventional formulation excipients, and mix well Granulate, pack size 0 capsules, 500mg each. Each capsule contains 450mg of traditional Chinese medicine composition. Usage: 4 capsules each time, 3 times a day, 7 days a week, 4 weeks as a course of treatment.

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PUM

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Abstract

The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicinal composition for treating intestinal mucosa damage after colorectal cancer surgery and (or) chemotherapy and a preparation method and application thereof. The traditional Chinese medicinal composition which is in accordance with the thinking of superior treat before sick in traditional Chinese medicine, adopts the rules of strengthening spleen, clearing heat and detoxifying and is prepared from the traditional Chinese medicines, such as 10 to 20 parts of codonopsis pilosula, 10 to 20 parts of atractylodes, 10 to 20 parts of poria cocos, 10 to 20 parts of stewed radix puerariae, 5 to 15 parts of scutellaria baicalensis, 3 to 15 parts of coptis chinensis and 10 to 20 parts of astragalus membranaceus, disclosed by the invention can be used for the adjuvant therapy of the intestinal mucosa damage after the colorectal cancer surgery and (or) the chemotherapy for a long time and the treatment of spleen deficiency and damp-heat syndrome of colorectal cancer. By the traditional Chinese medicinal composition, the clinical symptoms such as abdominal pain and diarrhea after the surgery and (or) the chemotherapy can be reduced obviously and has the effect of repairing the intestinal mucosa damage, so that the living quality of a patient is improved, the disease-free lifetime of the colorectal cancer is prolonged, and the effect-enhancing and toxicity-reducing effects are very good.

Description

Technical field: [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine compound preparation, in particular to a traditional Chinese medicine composition for treating intestinal mucosal injury, and a preparation method and application thereof. Background technique: [0002] In recent years, the incidence of colorectal cancer in my country has ranked third in malignant tumors. At present, surgical resection is the radical treatment for colorectal cancer. Chemotherapy and / or radiotherapy for patients with stage IIB or above or with high-risk factors after stage II surgery Routine postoperative treatment, but about 50% of colorectal cancer patients can have recurrence or metastasis within two years after radical surgery, and 70% of colorectal cancer patients can have liver and lung metastases. The metastasis of colorectal cancer is a difficult point in clinical treatment, and it is also one of the main causes of death ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/718A61P1/04
Inventor 王文海付晓伶周荣耀朱惠蓉
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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