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Preparation method for polymer micro-fluidic chip

A microfluidic chip, polymer technology, applied in chemical instruments and methods, laboratory containers, laboratory utensils, etc. Effect

Inactive Publication Date: 2013-09-11
苏州扬清芯片科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method requires at least two steps of ablation processing and chip sealing to prepare a microfluidic chip. The process is slightly cumbersome and requires two sets of corresponding instruments and equipment.

Method used

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  • Preparation method for polymer micro-fluidic chip
  • Preparation method for polymer micro-fluidic chip

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Preparation of a polymer microfluidic chip based on "fused deposition modeling" 3D printing technology

[0021] Fused deposition molding technology is to melt the material into a liquid state at a high temperature, and then extrude small spherical particles through a nozzle. These particles solidify immediately after being ejected, and form a physical object through the arrangement and combination of these particles in a three-dimensional space. PMMA is a thermoplastic material commonly used in the preparation of microfluidic chips. To prepare PMMA microfluidic chips using the method provided by the present invention, the three-dimensional structure of the microfluidic chip is drawn first, and then a "fused deposition molding" 3D printer is selected For example, the Stratasys 3D printer in the United States melts PMMA plastic in the printer nozzle, and then prepares microfluidic chips by depositing plastic fibers. Finally, the molded PMMA chip is heat treated at 8...

Embodiment 2

[0022] Example 2 Preparation of a polymer microfluidic chip based on "stereolithography" 3D printing technology

[0023] The three-dimensional lithography molding technology is to pass the liquid photocurable material through the printer nozzle to form an extremely thin liquid polymer coating on the tray, and this coating is then placed under ultraviolet light for curing. After that, the tray is lowered a very small distance for the next layer to be stacked, and finally the overall formation of the three-dimensional structure is completed. Photoresist, such as SU-8, is a commonly used material for microfluidic chips. To prepare SU-8 microfluidic chips using the method provided by the present invention, first draw the three-dimensional structure of the microfluidic chip, and then select "stereolithography "Forming" 3D printers, such as Israel’s Objet 3D printer, layer SU-8 photoresist layer by layer on the printer tray, and finally develop the formed SU-8 chip to achieve the forma...

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Abstract

The invention aims at providing a preparation method for a polymer micro-fluidic chip. The preparation method for the polymer micro-fluidic chip is characterized in that the polymer micro-fluidic chip is prepared by using a high-molecular polymer as a raw material, and adopting a 3D (three-dimensional) printing technology. The preparation method for the polymer micro-fluidic chip comprises the following specific preparation steps of: 1) designing and drawing the three-dimensional structure model of the micro-fluidic chip by computer-aided design software; 2) selecting a polymer material, and directly machining the micro-fluidic chip by a 3D printer; 3) performing forming post-treatment. The preparation method based on the 3D printing technology for the polymer micro-fluidic chip provided by the invention is low in machining cost, fast in speed, short in period, and capable of forming once. The method is especially suitable for scientific research laboratories or development work on micro-fluidic chip products, and extremely important in scientific and practical significance.

Description

Technical field [0001] The invention relates to the field of microfluidic chips, in particular to a rapid preparation method of polymer microfluidic chips. Background technique [0002] Since 1992, microfluidic chip technology has been widely used in chemistry, biology, medicine, physics and other fields. High polymer is one of the most common materials for preparing microfluidic chips. Because high polymer has the characteristics of low material cost and processing cost, suitable for mass production and preparation, it is especially suitable for scientific basic research and Two major areas of production and application. The current processing methods of polymer microfluidic chips are mainly divided into direct processing methods and indirect processing methods. Among them, the indirect preparation method based on mold replication is the most important processing method for polymer chips. This method is particularly suitable for The batch preparation of polymer chips has an im...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
Inventor 叶嘉明
Owner 苏州扬清芯片科技有限公司